apoN Activators
apoN Activators are a collection of chemical compounds that indirectly bolster the functionality of apoN by manipulating various biochemical signaling pathways. Forskolin raises cAMP levels, which activates PKA, known to phosphorylate proteins that could be integral to the apoN pathway, leading to an enhancement of apoN's role in cellular processes. Similarly, PMA, through PKC activation, and Ionomycin, by raising intracellular calcium levels, may phosphorylate and thereby enhance apoN's activity, assuming apoN is regulated by PKC or calcium-dependent kinases. The lipid molecule Sphingosine-1-phosphate, through G-protein coupled receptor activation, might modulate the actin cytoskeleton in a way that favors apoN's activation. Inhibitors like LY294002 and Genistein could potentially alleviate inhibitory controls.
apoN activators are diverse chemical entities that enhance apoN's functional activity by modulating specific cellular signaling cascades. Forskolin, through its elevation of intracellular cAMP, indirectly enhances apoN activity by activating protein kinase A (PKA), which can phosphorylate and activate proteins in the apoN signaling cascade, thereby enhancing apoN's functional role within cells. PMA, as a direct activator of protein kinase C (PKC), and Ionomycin, by increasing intracellular calcium concentrations, can initiate a series of phosphorylation events potentially leading to the activation of apoN if it is regulated by calcium-dependent phosphorylation. Sphingosine-1-phosphate, through its interaction with G-protein-coupled receptors, may activate downstream proteins that are part of the apoN pathway, thus promoting apoN's cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various proteins, including hypothetical targets in the apoN pathway, enhancing apoN's functional activity related to its specific cellular role. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC). PKC phosphorylates target proteins that are part of the signaling cascade in which apoN is involved, indirectly leading to enhancement of apoN's activity in signal transduction. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent protein kinases. These kinases could phosphorylate and activate apoN if apoN's activity is regulated by calcium-dependent phosphorylation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that activates G-protein coupled receptors, leading to downstream effects on the actin cytoskeleton and potentially enhancing the activity of apoN if it interacts with this pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter the PI3K/AKT pathway. By inhibiting PI3K, LY294002 might relieve negative feedback loops, indirectly enhancing signaling pathways that increase apoN activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can inhibit a range of kinases. Inhibition of these kinases might reduce negative regulation of apoN, indirectly enhancing its activity if apoN is negatively regulated by these kinases. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can lead to phosphorylation of proteins involved in apoN's signaling pathway, enhancing apoN's functional role. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, part of the MAPK pathway. Inhibition of MEK1/2 could shift signaling towards pathways in which apoN is active, thereby indirectly enhancing apoN's activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, it could redirect signaling to enhance apoN activity if apoN is part of a pathway antagonistic to p38 MAPK signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that raises intracellular calcium levels. Increased calcium can activate calcium-dependent signaling pathways, potentially enhancing the activity of apoN if it is regulated by calcium signaling. | ||||||