apoD Activators
The class of apoD activators encompasses a rich array of compounds that exert their influence on apoD through direct or indirect mechanisms, as elucidated in the tabulated form. These chemical activators interface with specific cellular pathways, intricately modulating the expression and activity of apoD. GW501516, a PPARδ agonist, stands out as a noteworthy example of a direct activator. Through binding to and activating PPARδ, GW501516 initiates a cascade of events that enhances the transcription of apoD. This interaction results in the elevated expression of apoD, contributing to subsequent cellular functions related to lipid metabolism and homeostasis. Similarly, AICAR, an AMP-activated protein kinase (AMPK) activator, directly activates apoD by engaging the AMPK pathway. By stimulating AMPK, AICAR triggers downstream signaling cascades that positively regulate transcription factors involved in apoD expression, further emphasizing the multifaceted regulatory role of these activators.
Forskolin, as another direct activator, operates through a distinct mechanism. By stimulating adenylate cyclase, Forskolin increases intracellular cAMP levels. Elevated cAMP, in turn, activates protein kinase A (PKA), influencing transcription factors crucial for apoD expression. These direct interactions underscore the intricate connections between chemical activators and the specific cellular pathways governing apoD activation. The comprehensive understanding of these activators and their precise biochemical actions provides valuable insights into the modulation of apoD and its implications in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
GW501516 is a PPARδ agonist that directly activates apoD. By binding to and activating PPARδ, it enhances the transcription of apoD, promoting its expression and subsequent cellular functions. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR, an AMP-activated protein kinase (AMPK) activator, directly activates apoD. It stimulates AMPK, which phosphorylates and activates various downstream targets, including transcription factors involved in apoD expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a sirtuin activator, directly influences apoD activation. By activating sirtuins, particularly SIRT1, it modulates transcriptional regulators that positively impact apoD expression and cellular functions. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone is a PPARγ agonist that directly activates apoD. Binding to PPARγ, it promotes the transcription of apoD, enhancing its expression and cellular functions related to lipid metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates apoD by stimulating adenylate cyclase, leading to increased cAMP levels. Elevated cAMP activates protein kinase A (PKA), which in turn influences transcription factors involved in apoD expression. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid directly activates apoD by influencing the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) pathway. It enhances PGC-1α activity, promoting apoD expression and cellular functions. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662 is an AMP-activated protein kinase (AMPK) activator that directly activates apoD. By stimulating AMPK, it initiates downstream signaling cascades that positively regulate transcription factors involved in apoD expression. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, a PPARγ agonist, directly activates apoD. Binding to PPARγ, it enhances the transcription of apoD, promoting its expression and cellular functions related to lipid metabolism. | ||||||
GSK 4716 | 101574-65-6 | sc-203986 sc-203986A | 10 mg 50 mg | $71.00 $285.00 | ||
GSK4716 is a PPARδ agonist that directly activates apoD. By binding to and activating PPARδ, it enhances the transcription of apoD, promoting its expression and subsequent cellular functions. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylate directly activates apoD by inhibiting NF-κB. By suppressing NF-κB activity, it alleviates its inhibitory effect on apoD expression, allowing for enhanced transcription and subsequent cellular functions. | ||||||