Apg12 Activators
APG12 (Autophagy-related protein 12) is a key component in the autophagy pathway, a critical cellular process for maintaining homeostasis through the degradation and recycling of cellular components. Autophagy is particularly important under conditions of stress, such as nutrient deprivation, where it helps to sustain cellular metabolism by recycling nutrients from non-essential components.APG12 is best known for its role in the formation of autophagosomes, which are double-membrane vesicles that encapsulate cellular material destined for degradation. The functionality of APG12 is closely linked to its conjugation with another protein, APG5 (Autophagy-related protein 5). This conjugation, facilitated by the enzymes APG7 and APG10, is essential for the expansion of the autophagosomal membrane.
The APG12-APG5 conjugate associates with another protein, APG16L, forming a complex that is critical for the elongation and closure of the autophagosomal membrane. This complex is key in identifying and sequestering cytoplasmic components, including damaged organelles and misfolded proteins, into the autophagosome.Defects in the autophagy pathway, including dysregulation of APG12, can have significant implications. Impaired autophagy has been linked to various diseases, including neurodegeneration, cancer, and infections. APG12's role in autophagy also makes it a target for interventions in these diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, known to activate autophagy through mTOR inhibition, might upregulate APG12 expression as part of the autophagic response. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1, another mTOR inhibitor, could enhance APG12 expression by promoting autophagy under nutrient stress conditions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol might influence APG12 expression due to its role in activating sirtuin pathways, which are linked to autophagy. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin, often used in diabetes, could potentially increase APG12 expression by modulating AMPK activity and autophagy. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine, known for inducing autophagy, may upregulate APG12 expression as part of its role in cellular aging and stress response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may modulate APG12 expression through its anti-inflammatory effects and potential role in inducing autophagy. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium might affect APG12 expression through pathways related to neuroprotection and autophagic processes. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine, by altering lysosomal pH, could potentially influence APG12 expression in the context of autophagy modulation. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine, similar to hydroxychloroquine, might upregulate APG12 in the process of inhibiting the late stages of autophagy. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $30.00 $167.00 $260.00 | 2 | |
Trehalose could enhance APG12 expression due to its role in promoting autophagy, especially under stress conditions. | ||||||