APC16 Activators
Anaphase promoting complex subunit 16 (APC16) is a component of the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase that plays a pivotal role in cell cycle control by mediating the ubiquitination and subsequent proteasomal degradation of target proteins. The APC/C complex regulates the metaphase-to-anaphase transition and the exit from mitosis into the G1 phase.APC16, being a part of this complex, is integral to its function. It's one of the smallest subunits of the APC/C and is involved in binding other subunits to maintain the stability and functionality of the complex. APC16 is required for the integrity of the APC/C complex and consequently for its ability to mediate the ubiquitination of its target substrates.
The APC/C complex, including APC16, is regulated by several mechanisms such as the binding of coactivator proteins CDC20 and CDH1, phosphorylation, and the spindle assembly checkpoint. This ensures that the APC/C functions at the appropriate time in the cell cycle.Aberrations in the function of the APC/C, potentially involving APC16, can lead to improper cell cycle control and genomic instability, which are hallmarks of many cancers. Furthermore, overexpression of APC/C components has been linked to poor prognosis in several types of cancer.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
May upregulate APC16 by reducing methylation levels at its gene promoter, altering gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, it could promote a more open chromatin state, potentially increasing APC16 transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By elevating cAMP, forskolin might enhance APC16 expression through activation of cAMP response element-binding protein (CREB). | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Could modulate gene expression during cellular differentiation, potentially affecting APC16 levels. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which may influence APC16 expression via PKC-mediated signaling pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As an HDAC inhibitor, it might increase APC16 expression by altering histone acetylation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Known to modulate gene expression; could potentially affect APC16. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Through modulating GSK-3β activity and other pathways, lithium could influence APC16 expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Induces ER stress and the unfolded protein response, which could affect APC16 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Glucocorticoids can regulate gene expression and might alter APC16 levels during stress response. | ||||||