APC1 Activators
APC1 activators are a class of chemical compounds that modulate the activity of the Anaphase-Promoting Complex/Cyclosome subunit 1 (APC1), which is a pivotal component of the eukaryotic cell cycle. The Anaphase-Promoting Complex, also known as the Cyclosome (APC/C), is an E3 ubiquitin ligase that plays a crucial role in regulating various stages of the cell cycle by marking target cell cycle proteins for degradation via the ubiquitin-proteasome system. The complex ensures proper cell cycle progression by triggering the transition from metaphase to anaphase, during which it targets securin and cyclins for degradation, thereby controlling the onset of anaphase and exit from mitosis.
APC1 activators work by either directly interacting with the APC1 subunit to enhance its activity or by influencing the regulatory pathways that modulate the APC/C complex's functionality. For instance, these activators may stabilize the complex, enhance its binding to substrates, or facilitate the recruitment of essential coactivators such as Cdc20 or Cdh1, which are necessary for substrate recognition. The exact mechanism of action of APC1 activators can vary depending on the specific molecular structure and the pathway targeted by the compound. Some activators may bind to APC1 and induce a conformational change that increases the APC/C's affinity for its substrates or its ubiquitin ligase activity. Others might act indirectly by inhibiting the deactivators or regulatory phosphatases that suppress APC/C activity, thereby tipping the balance towards activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that activates autophagy, a cellular process that APC1 could be involved in or regulated by. Therefore, Rapamycin can indirectly lead to an increase in APC1 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a SIRT1 activator. SIRT1 is a protein deacetylase, and its activation could potentially enhance the activity of APC1 if it's involved in or regulated by similar pathways. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone is a PPARγ activator. PPARγ is a transcription factor that regulates the expression of certain genes; if APC1 is a part of these pathways, its activity can be enhanced by Troglitazone. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an adenylate cyclase activator. Adenylate cyclase is crucial for the cAMP-dependent pathway, and its activation can potentially lead to the enhancement of APC1 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that could indirectly activate APC1, as PI3K is an upstream regulator of mTOR, therefore its inhibition could increase autophagy and indirectly APC1 activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a HDAC inhibitor, which can lead to hyperacetylation of proteins and could modulate the function of APC1 if it's involved in or regulated by these pathways. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin activates AMPK, a master regulator of cellular energy homeostasis. The activation of AMPK can potentially enhance the activity of APC1 if the protein is involved in this pathway. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMPK activator. AMPK activation can potentially influence APC1 activity if it's involved in the energy-sensing AMPK pathway. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can activate retinoic acid receptor (RAR) signaling pathways, which can indirectly influence APC1 if it's involved in these pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone activates glucocorticoid receptors, which can indirectly influence APC1 if it's involved in these pathways. | ||||||