AP-3μ2 Inhibitors
AP-3μ2 inhibitors are chemical compounds that directly or indirectly influence the function of AP-3μ2, a protein involved in vesicle formation, transport, and lysosomal trafficking. Inhibitors like Bafilomycin A1 and Chloroquine disrupt the normal acidification and maturation of vesicles and lysosomes,respectively, interfering with the biological processes that AP-3μ2 is involved in. Other inhibitors, Monensin and Dynasore, alter ion gradients and inhibits the scission of newly formed vesicles from the membrane, respectively, thus disrupting vesicle trafficking, a critical function of AP-3μ2.
On the other hand, Colchicine, Vincristine, and Nocodazole act on the microtubule network, which plays a pivotal role in vesicle transport, a process directly linked with AP-3μ2 function. By disrupting microtubule assembly and promoting their depolymerization, these inhibitors can indirectly lead to decreased functional activity of AP-3μ2. Furthermore, Latrunculin A, Cytochalasin D, and Jasplakinolide, which modulate actin polymerization and dynamics, indirectly impact the vesicle transport process that AP-3μ2 facilitates. Lastly, Wortmannin and LY294002, as PI3K inhibitors, can disrupt vesicle trafficking by inhibiting the PI3K-dependent pathway, thereby influencing the function of AP-3μ2. By targeting these various pathways and processes, these chemical compounds are able to induce functional inhibition of AP-3μ2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of vacuolar-type H+-ATPase (V-ATPase). The AP-3μ2 protein is involved in vesicle formation and transport, thus the inhibition of V-ATPase by Bafilomycin A1 can disrupt vesicle acidification and maturation, indirectly leading to decreased functional activity of AP-3μ2. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is an antimalarial drug that inhibits lysosomal acidification. As AP-3μ2 is involved in lysosomal trafficking, inhibition of lysosomal acidification by Chloroquine can disrupt the normal function of AP-3μ2. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a sodium ionophore that disrupts vesicle trafficking by altering ion gradients. As AP-3μ2 is involved in vesicle formation and trafficking, the disruption of ion gradients by Monensin can indirectly inhibit the functional activity of AP-3μ2. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a dynamin inhibitor that prevents the scission of newly formed vesicles from the membrane. The inhibition of dynamin by Dynasore can disrupt the vesicle formation process, which can lead to decreased functional activity of AP-3μ2. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine is a drug that inhibits microtubule polymerization. As AP-3μ2 is involved in vesicle transport along microtubules, the inhibition of microtubule polymerization by Colchicine can disrupt the transport process, leading to decreased functional activity of AP-3μ2. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent. As AP-3μ2 is involved in vesicle transport along microtubules, the depolymerization of microtubules by Nocodazole can disrupt the transport process, leading to decreased functional activity of AP-3μ2. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A is an actin polymerization inhibitor. As AP-3μ2 is involved in vesicle transport and actin can facilitate this process, the inhibition of actin polymerization by Latrunculin A can disrupt the transport process, leading to decreased functional activity of AP-3μ2. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is an inhibitor of actin polymerization. As AP-3μ2 is involved in vesicle transport and actin can facilitate this process, the inhibition of actin polymerization by Cytochalasin D can disrupt the transport process, leading to decreased functional activity of AP-3μ2. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is an actin filament stabilizer that can disrupt normal actin dynamics. Since AP-3μ2 is involved in vesicle transport and actin can facilitate this process, the disruption of normal actin dynamics by Jasplakinolide can disrupt the transport process, leading to decreased functional activity of AP-3μ2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor that can disrupt vesicle trafficking by inhibiting the PI3K-dependent pathway. As AP-3μ2 is involved in vesicle trafficking, the inhibition of PI3K by Wortmannin can lead to decreased functional activity of AP-3μ2. | ||||||