ANUBL1 Activators
ANUBL1 Activators are a collection of chemical compounds that indirectly influence the functional activity of ANUBL1 by modulating various signaling pathways. Forskolin and IBMX, by increasing intracellular levels of cAMP, lead to the activation of PKA, which may phosphorylate enzymes that directly enhance the activity of ANUBL1. PMA, through its activation of PKC, and Ionomycin, by raising intracellular calcium concentrations, might stimulate kinase pathways that phosphorylate and activate ANUBL1. Epigallocatechin gallate, by inhibiting certain kinases, could alleviate inhibitory phosphorylation on ANUBL1, while Sildenafil, by preserving cGMP levels, may activate PKG which can phosphorylate proteins in the ANUBL1 pathway. A23187, similar to Ionomycin, raises calcium levels, potentially influencing ANUBL1 activation through calcium-dependent signaling pathways. LY294002 disrupts the PI3K/AKT pathway, possibly allowing for the enhancement of ANUBL1 activity by lifting negative regulation.
Further influencing the activity of ANUBL1, U73122 impedes PLC function,which may result in the alteration of downstream signaling and a potential increase in ANUBL1 activity due to the reduction of inhibitory influences. Okadaic acid, by inhibiting protein phosphatases, could cause an accumulation of phosphorylated proteins, including ANUBL1, leading to enhanced activity. Anisomycin, while inhibiting protein synthesis, also activates SAPKs, which may phosphorylate and thereby activate ANUBL1 signaling proteins. Lastly, Zaprinast boosts cGMP levels, which could engage PKG in pathways that enhance ANUBL1 activity. Collectively, these activators operate through distinct mechanisms but converge on the common outcome of promoting ANUBL1 functional activity by influencing phosphorylation states and signaling cascades relevant to ANUBL1's role in the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing levels of cyclic AMP (cAMP) in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate other enzymes including those that may directly increase the activity of ANUBL1 by phosphorylation at specific serine/threonine residues. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases. By preventing the breakdown of cAMP, IBMX raises intracellular levels of this secondary messenger, indirectly enhancing the ANUBL1 activity via similar PKA-mediated phosphorylation pathways as Forskolin. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) directly activates protein kinase C (PKC), which then influences numerous downstream targets, including potentially ANUBL1, through phosphorylation events that alter its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations, potentially activating calcium-dependent kinases such as calmodulin-dependent kinase (CaMK), which could phosphorylate and thereby activate ANUBL1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol found in green tea that inhibits certain types of kinases, which could reduce negative regulatory phosphorylation, therefore enhancing ANUBL1's functional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that raises intracellular calcium levels, which may activate signaling pathways involving calcium-dependent proteins that could enhance ANUBL1 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that by decreasing PI3K/AKT pathway activity may relieve negative feedback loops, indirectly enhancing ANUBL1 activity by allowing upregulation of pathways in which ANUBL1 is involved. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. Inhibition of these phosphatases could lead to an increase in phosphorylated proteins, possibly including ANUBL1, thereby enhancing its activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases (SAPKs). Activation of SAPKs could lead to phosphorylation and activation of proteins within the ANUBL1 signaling pathway. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits phosphodiesterases, leading to increased levels of cGMP, which may enhance ANUBL1 activity through pathways that involve cGMP-dependent protein kinases or PKG. | ||||||