ANP32C Activators
ANP32C activators are a group of chemicals that indirectly enhance the function of ANP32C by influencing the PP2A and PKC pathways. The first eight compounds listed here are inhibitors of PP2A, a protein that ANP32C is known to inhibit. By further inhibiting PP2A, these compounds could logically enhance the inhibitory action of ANP32C on PP2A. These PP2A inhibitors include cantharidin, fostriecin, calyculin A, microcystin LR, norcantharidin, rubratoxin B, and tautomycin.
The last four compounds-demethylasterriquinone B1, bryostatin 1, phorbol 12-myristate 13-acetate (PMA), and ingenol 3-angelate-are PKC activators. PKC can phosphorylate ANP32C, which could possibly enhance its function. Hence, by activating PKC, these compounds could indirectly lead to increased activity of ANP32C. This group of ANP32C activators therefore comprises compounds that can influence the PP2A and PKC pathways to indirectly enhance the function of ANP32C
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin is another inhibitor of PP2A. Similar to okadaic acid, it could indirectly enhance the activity of ANP32C by inhibiting PP2A. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $265.00 | 9 | |
Fostriecin specifically inhibits PP2A, and could therefore indirectly increase the inhibitory activity of ANP32C on PP2A. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a strong inhibitor of PP1 and PP2A. It could indirectly enhance the activity of ANP32C by inhibiting PP2A. | ||||||
Norcantharidin | 29745-04-8 | sc-280719 | 5 g | $113.00 | 2 | |
Norcantharidin, a demethylated analog of cantharidin, also inhibits PP2A, and thus could enhance ANP32C function indirectly. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 is a PKC activator that can also phosphorylate ANP32C and potentially enhance its function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent PKC activator that can phosphorylate ANP32C, possibly enhancing its function. | ||||||
Ingenol 3-angelate | 75567-37-2 | sc-364214 sc-364214A | 1 mg 5 mg | $189.00 $734.00 | 3 | |
Ingenol 3-angelate is a PKC activator that can phosphorylate ANP32C, potentially enhancing its function. | ||||||