ANKRD27 Inhibitors
ANKRD27 Inhibitors consist of a diverse array of chemicals that impinge on the functional activity of ANKRD27 by targeting various signaling pathways and cellular processes that ANKRD27 is involved in. ANKRD27 is a protein associated with vesicular trafficking, particularly functioning with the retromer complex, which is crucial for the sorting and transport of proteins within the endosomal-lysosomal system. Wortmannin and LY294002 are PI3K inhibitors that prevent the formation of PIP3, a phospholipid that plays a pivotal role in membrane dynamics and vesicular trafficking. By inhibiting PI3K activity, these compounds can impede the trafficking of vesicles, thereby indirectly inhibiting the functionality of ANKRD27, which is contingenton the proper formation and transport of these vesicles. Similarly, Dynasore, a dynamin inhibitor, can hinder the scission of vesicles from the membrane, a crucial step in which ANKRD27 is implicated. Brefeldin A and Monensin disrupt Golgi structure and function, further impeding vesicular transport and indirectly diminishing ANKRD27's role in these processes.
The act of inhibiting cytoskeletal components, which are essential for the movement of vesicles within cells, is another strategy to dampen ANKRD27's activity. Compounds like Nocodazole and Paclitaxel exert their effects by either depolymerizing or stabilizing microtubules, respectively, disrupting the balance necessary for efficient vesicle transport. Cytochalasin D and Latrunculin A work on the actin cytoskeleton, either by blocking actin polymerization or by sequestering actin monomers, which can impede the trafficking mechanism where ANKRD27 is vital. By altering cytoskeletal dynamics, these compounds indirectly limit ANKRD27 function. ML141, as a Cdc42 inhibitor, affects actin cytoskeleton organization; since Cdc42 is involved in actin filament assembly necessary for vesicular movement, this inhibition can reduce ANKRD27-mediated transport. Genistein's inhibition of tyrosine kinases alters signaling pathways that can cascade down to affect vesicular trafficking, potentially impacting ANKRD27's associated functions. Lastly, Chlorpromazine, while known for its antipsychotic properties, can also inhibit clathrin-mediated endocytosis, a process integral to ANKRD27's role in vesicle formation and movement, thus indirectly inhibiting the protein's activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor that prevents the phosphorylation of PIP2 to PIP3, reducing the activity of downstream effectors including AKT. ANKRD27 is known to interact with VPS35, which is part of the retromer complex involved in trafficking of PI3K products. Inhibition of PI3K by Wortmannin can impair retromer function, thereby indirectly inhibiting ANKRD27. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of PI3K that blocks the formation of PIP3 from PIP2, leading to reduced activation of AKT. Reduced AKT activity can affect vesicular trafficking pathways where ANKRD27 is implicated, resulting in decreased ANKRD27 function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
GTPase inhibitor that blocks the function of dynamin, a protein involved in endocytosis and vesicular trafficking. Since ANKRD27 is associated with vesicular transport, inhibiting dynamin can indirectly reduce ANKRD27-mediated vesicle formation and transport. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Inhibitor of ADP-ribosylation factor (ARF), a small GTPase involved in the formation of vesicular tubular clusters. Inhibition of ARF can lead to disruption of vesicular trafficking, thus potentially impairing ANKRD27-dependent vesicle transport processes. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Ionophore that disrupts the Golgi apparatus and alters intracellular trafficking. By affecting the Golgi, Monensin can indirectly inhibit ANKRD27 which is important for the endosomal sorting and trafficking pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Tyrosine kinase inhibitor that can alter various signaling pathways including those involved in vesicle trafficking. ANKRD27, through its association with vesicle formation, may be functionally inhibited by the disrupted signaling caused by Genistein. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Microtubule depolymerizer that can disrupt the cytoskeleton and associated transport mechanisms. ANKRD27's role in vesicular trafficking is dependent on an intact microtubule network, so Nocodazole can indirectly inhibit ANKRD27 function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Actin polymerization inhibitor that disrupts actin filaments, affecting cell shape and transport. ANKRD27, which is involved in trafficking, may be indirectly inhibited by the impaired vesicle movement due to cytoskeletal disruption. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Antipsychotic drug that can block dopamine receptors and also known to affect clathrin-mediated endocytosis. As ANKRD27 is involved in vesicular transport, Chlorpromazine can indirectly inhibit ANKRD27 by disrupting clathrin-mediated trafficking. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
Cdc42 inhibitor that affects actin cytoskeleton organization and vesicle trafficking. Given ANKRD27's role in vesicular transport, inhibition of Cdc42 by ML141 can lead to functional inhibition of ANKRD27. | ||||||