ANGEL2 Activators
NGEL2 Activators consist of a variety of chemicals that directly or indirectly stimulate the functional activation of ANGEL2 through specific signaling pathways. Forskolin, Epinephrine, and Isoproterenol, for instance, activate adenylyl cyclase which leads to an increase in cAMP levels. This elevation in cAMP then triggers PKA, which can phosphorylate and activate ANGEL2. This series of events showcases how these chemicals directly influence the functional activity of ANGEL2. In contrast, Phorbol 12-Myristate 13-Acetate (PMA) operates through a different mechanism, activating protein kinase C (PKC) which can then phosphorylate and stimulate ANGEL2.
Other ANGEL2 Activators, such as Okadaic Acid and Calyculin A, operate by inhibiting deactivating enzymes, leading to sustained activation of ANGEL2. These chemicals inhibit protein phosphatases 1 and 2A, enzymes responsible for the dephosphorylation and consequent deactivation of ANGEL2. By obstructing these enzymes, Okadaic Acid and Calyculin A prevent the deactivation of ANGEL2, leading to its continued activation. Similarly, H-89 and Staurosporine inhibit protein kinases, resulting in the upregulation of cAMP levelsand indirectly encouraging ANGEL2 activation. This inhibition of protein kinases, including PKA and PKC, alters cellular signaling pathways and can indirectly stimulate ANGEL2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP levels. The elevated cAMP levels can activate PKA. PKA then phosphorylates and activates ANGEL2. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA leads to phosphorylation and activation of ANGEL2. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates adrenergic receptors, leading to an increase in cyclic AMP levels. The elevated cAMP activates PKA, which can phosphorylate and activate ANGEL2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterase, an enzyme that degrades cAMP. By inhibiting phosphodiesterase, IBMX can increase cAMP levels, leading to the activation of PKA and subsequently ANGEL2. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol activates β-adrenergic receptors, leading to an increase in cAMP levels. The elevated cAMP activates PKA, which can in turn activate ANGEL2. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram selectively inhibits phosphodiesterase 4 (PDE4). By inhibiting PDE4, Rolipram can increase cAMP levels, leading to the activation of PKA and subsequently ANGEL2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC). PKC activation can lead to phosphorylation and activation of ANGEL2. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid inhibits protein phosphatases 1 and 2A. By inhibiting these phosphatases, Okadaic Acid prevents dephosphorylation, allowing for sustained activation of ANGEL2. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A. By inhibiting these phosphatases, Calyculin A can lead to sustained activation of ANGEL2. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC. Inhibition of PKC can lead to altered cellular signaling pathways, indirectly leading to the activation of ANGEL2. | ||||||