AMZ1 Activators
AMZ1 Activators are a diverse group of chemical compounds that interact with cellular signaling pathways to enhance the functional activity of the AMZ1 protein. Forskolin, by increasing cAMP levels, facilitates PKA activation, which may lead to the phosphorylation and subsequent enhancement of AMZ1 activity. Ionomycin, through its ionophore activity, raises intracellular calcium levels, which in turn activates calcium-dependent kinases that can enhance the activity of AMZ1. The activation of PKC by PMA could catalyze phosphorylation events that, if AMZ1 is a substrate or associated with PKC signaling, would result in its enhanced activity. The activation of the insulin receptor by insulin and the EGF receptor by EGF engages the PI3K/Akt and MAPK/ERK pathways, respectively, which can lead to the phosphorylation of many proteins, including AMZ1.
Other compounds such as Lithium chloride and Retinoic acid alter the stability and expression of proteins through the inhibition of GSK-3 and modulation of gene expression via nuclear receptors, respectively. These changes can lead to the upregulation of AMZ1 activity. Compounds like Curcumin and Resveratrol, by inhibiting NF-κB and activating SIRT1, respectively, can modify the expression and activity of proteins, including AMZ1. H-89, while primarily a PKA inhibitor, can also affect other kinases that may regulate AMZ1, leading to an indirect enhancement of AMZ1's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can activate protein kinase A (PKA), which may then phosphorylate a variety of proteins, including AMZ1, potentially enhancing AMZ1's functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Increased calcium can activate calcium-dependent signaling pathways, such as calmodulin-dependent kinases, which can then enhance the activity of proteins like AMZ1 that are regulated by calcium signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC). PKC activation can lead to downstream phosphorylation events that enhance the activity of proteins involved in the PKC signaling pathway, potentially including AMZ1. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the insulin receptor, triggering the PI3K/Akt signaling pathway. Akt, in turn, can enhance the function of a range of proteins through phosphorylation, which may include AMZ1 if it is part of this pathway. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3). Inhibition of GSK-3 can stabilize β-catenin, which may enter the nucleus and affect the transcription of proteins, possibly enhancing the functional activity of AMZ1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid affects gene expression through its nuclear receptors. This influence on gene expression can lead to altered protein function, including proteins like AMZ1 if involved in retinoic acid-regulated pathways. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
This active form of vitamin D engages with its nuclear receptor to modulate gene expression. The resultant changes can include the enhanced activity of proteins involved in calcium homeostasis, potentially encompassing AMZ1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known to inhibit NF-κB, a transcription factor involved in the inflammatory response. Inhibition of NF-κB can result in the altered expression of proteins involved in inflammation, potentially enhancing the activity of AMZ1 through related pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), which deacetylates proteins and impacts their function. Through SIRT1 activation, resveratrol can enhance the activity of proteins like AMZ1 if they are substrates or part of sirtuin-regulated pathways. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is known as a PKA inhibitor, but it can have off-target effects and influence other kinases. If AMZ1 is regulated by these kinases, H-89 could lead to enhanced AMZ1 activity through its broader kinase modulation. | ||||||