ALS2CR12 Activators
Chemical activators of ALS2CR12 encompass a variety of compounds that engage distinct signaling pathways to modulate the protein's activity. Forskolin, a direct stimulator of adenylyl cyclase, elevates cyclic AMP levels, which can activate protein kinase A (PKA). PKA, in turn, can phosphorylate ALS2CR12, assuming it is a substrate or is regulated by a PKA-dependent mechanism. Similarly, IBMX raises intracellular cAMP concentrations by inhibiting phosphodiesterases, thereby indirectly enhancing PKA activity and potentially fostering the phosphorylation and subsequent activation of ALS2CR12. PMA operates through a different route, activating protein kinase C (PKC), which can phosphorylate ALS2CR12 if it is involved in a PKC-dependent pathway.
Diverse molecules like spermidine and epigallocatechin gallate (EGCG) engage autophagy and AMPK pathways, respectively. Spermidine can trigger autophagy and, if ALS2CR12 is associated with or regulated through autophagic processes, this could lead to its activation. EGCG, known for its ability to activate AMPK, could similarly influence ALS2CR12 if it is aligned with AMPK-regulated pathways. Metformin and AICAR, both recognized as AMPK activators, can also facilitate the activation of ALS2CR12 through stimulating this energy-sensing kinase. In contrast, resveratrol activates SIRT1, which may contribute to ALS2CR12 activation if it relies on deacetylation or SIRT1-influenced pathways. Retinoic acid, by modulating gene expression, could also indirectly activate ALS2CR12 if it is involved in cellular differentiation pathways influenced by this compound. Additionally, hydrogen peroxide and zinc sulfate might activate ALS2CR12 through oxidative stress pathways and zinc signaling, respectively, provided ALS2CR12 is sensitive to redox changes or contains zinc-binding domains. Lastly, sodium orthovanadate can promote the activation of ALS2CR12 by inhibiting tyrosine phosphatases, potentially enhancing the phosphorylated state of the protein if it is regulated by tyrosine phosphorylation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can then activate protein kinase A (PKA), which may phosphorylate and activate ALS2CR12 as part of downstream signaling, assuming ALS2CR12 is a substrate for PKA or is regulated by a PKA-dependent pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX acts as a nonspecific inhibitor of phosphodiesterases, enzymes that degrade cAMP. By preventing cAMP breakdown, IBMX indirectly increases cAMP levels, which can activate PKA. PKA, in turn, could phosphorylate and activate ALS2CR12 if ALS2CR12 is part of a PKA-dependent pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA, or phorbol 12-myristate 13-acetate, activates protein kinase C (PKC). If ALS2CR12 is regulated by a PKC-dependent pathway, PKC activation by PMA could lead to the phosphorylation and activation of ALS2CR12. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine can enhance autophagy through the activation of AMPK. If ALS2CR12 is involved in autophagic processes or its activity is modulated through autophagy, then spermidine could activate ALS2CR12 by promoting these pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate SIRT1, a member of the sirtuin family of NAD+-dependent deacetylases. If ALS2CR12 function is enhanced by deacetylation or is involved in pathways regulated by SIRT1, resveratrol could indirectly lead to the activation of ALS2CR12. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMP-activated protein kinase (AMPK). If ALS2CR12 is part of an AMPK-regulated pathway or its activity is modulated by AMPK signaling, then metformin-induced activation of AMPK could result in the functional activation of ALS2CR12. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) can modulate several signaling pathways and has been shown to activate AMPK. If ALS2CR12 operates within or downstream of AMPK signaling pathways, EGCG could activate ALS2CR12 through AMPK activation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an activator of AMPK. Similar to metformin, if ALS2CR12 is involved in pathways regulated by AMPK, AICAR's activation of AMPK could lead to the functional activation of ALS2CR12. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate gene expression and cellular differentiation pathways. If ALS2CR12 is involved in such pathways or is activated by signaling cascades influenced by retinoic acid, then retinoic acid could indirectly lead to its activation. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide can act as a signaling molecule leading to the activation of various kinases through oxidative stress pathways. If ALS2CR12 is part of a pathway that includes redox-sensitive kinases, then hydrogen peroxide could lead to ALS2CR12 activation through oxidative signaling modifications. | ||||||