α4-crystallin Inhibitors
α4-Crystallin inhibitors represent a unique class of chemical compounds that target the α4 subunit of crystallin proteins, specifically interfering with their molecular interactions and structural functions. Crystallins are a family of structural proteins primarily known for their role in maintaining the transparency and refractive index of the eye lens, though they also exhibit properties outside ocular tissues. Among the crystallins, the α-crystallins are small heat shock proteins (sHSPs) that function as molecular chaperones, preventing the aggregation of unfolded proteins and stabilizing cellular proteins under stress conditions. The α4 subunit is an isoform that can be distinguished by its unique amino acid sequences and specific structural motifs, which confer it distinct biochemical properties compared to other crystallin subunits.
Inhibitors of α4-crystallin work by binding to these proteins, disrupting their chaperone activity and altering their ability to maintain protein stability, particularly in response to cellular stress. The molecular mechanisms of these inhibitors often involve steric hindrance or allosteric modulation, which can affect the protein's conformational flexibility and interaction with other cellular components. Researchers study these inhibitors to understand better the role of α4-crystallin in various molecular processes, including its participation in cellular homeostasis, protein folding, and response to oxidative stress. By inhibiting the function of α4-crystallin, scientists can investigate the broader implications of protein-protein interactions within cellular systems and explore how such interventions may affect the overall stability of protein complexes within different physiological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin has been shown to inhibit the expression of heat shock proteins, which may include αA-crystallin, through the disruption of heat shock protein function. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A has been studied for its potential to inhibit the expression of heat shock proteins, including αA-crystallin, by interfering with heat shock protein signaling pathways. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG (17-allylamino-17-demethoxygeldanamycin) has been investigated for its potential to inhibit the expression of heat shock proteins, potentially including αA-crystallin, through disruption of heat shock protein function. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $90.00 $326.00 | 13 | |
Radicicol has been reported to inhibit the expression of heat shock proteins, which may include αA-crystallin, by interfering with the function or stability of heat shock proteins. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin has been found to inhibit the expression of heat shock proteins, potentially including αA-crystallin, by modulating specific signaling pathways involved in heat shock protein regulation. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol has been studied for its potential to inhibit the expression of heat shock proteins, including αA-crystallin, through its effects on heat shock protein regulatory mechanisms. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG has been reported to inhibit the expression of heat shock proteins, potentially including αA-crystallin, by modulating signaling pathways involved in the regulation of heat shock protein expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide has been investigated for its potential to inhibit the expression of heat shock proteins, which may include αA-crystallin, through its effects on heat shock protein regulatory mechanisms. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin has demonstrated the ability to inhibit the expression of heat shock proteins, potentially including αA-crystallin, by modulating specific signaling pathways involved in the regulation of heat shock protein expression. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol has been found to inhibit the expression of heat shock proteins, potentially including αA-crystallin, by modulating specific signaling pathways involved in the regulation of heat shock protein expression. | ||||||