α4-crystallin Activators
Chemical activators of α4-crystallin can exert their effects through various mechanisms associated with the stabilization and proper folding of proteins. Phenylbutyrate, for instance, activates the heat shock response, which includes the induction of molecular chaperones such as α4-crystallin, thereby enhancing its ability to assist in protein folding and stability. Similarly, geranylgeranylacetone can lead to an increase in α4-crystallin activity by inducing heat shock proteins that encompass molecular chaperones. This serves to augment the protective functions of α4-crystallin in cellular environments. Trehalose, a disaccharide, stabilizes proteins and, in turn, can enhance the activation of α4-crystallin by promoting its structural integrity and preventing aggregation. Dimethyl sulfoxide, known for its ability to induce heat shock proteins, can also contribute to the activation of α4-crystallin, thereby enhancing its chaperone capabilities.
Compounds like arimoclomol and bimoclomol act by amplifying the heat shock response, which potentially increases the levels of α4-crystallin, thus promoting its activation and chaperone activity. Essential elements such as zinc can function as cofactors, playing a role in the structural stabilization of α4-crystallin, which is crucial for its activity. Additionally, selenium, as part of the antioxidant defense system, can support the structural and functional maintenance of α4-crystallin under oxidative stress conditions. Tauroursodeoxycholic acid, known for aiding in cellular homeostasis, can also contribute to the stabilization and activation of α4-crystallin during stress. Further, curcumin and resveratrol, both of which upregulate heat shock protein expression, can activate α4-crystallin by preventing protein aggregation and enhancing its efficiency as a chaperone. Lastly, the compound 17-AAG, which inhibits Hsp90, can indirectly lead to the upregulation and activation of heat shock proteins, including α4-crystallin, thus promoting its chaperone function within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
Phenylbutyrate activates the heat shock response, which can lead to the induction of molecular chaperones such as α4-crystallin. These chaperones assist in protein folding and can enhance the stability and function of α4-crystallin. | ||||||
Geranylgeranylacetone | 6809-52-5 | sc-252851 sc-252851A | 10 mg 100 mg | $65.00 $155.00 | 2 | |
Geranylgeranylacetone induces heat shock proteins, which can include α4-crystallin. By enhancing the levels of these chaperones, α4-crystallin activation and protective functions in cells are increased. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $29.00 $164.00 $255.00 | 2 | |
Trehalose stabilizes proteins and enhances their proper folding, which could lead to an increase in α4-crystallin activity by stabilizing its quaternary structure and preventing aggregation. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
Dimethyl sulfoxide has been known to induce heat shock proteins, potentially including α4-crystallin, leading to its increased activation and chaperone function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc can act as a cofactor for many proteins and may be involved in the structural stabilization of α4-crystallin, thus enhancing its chaperone activity. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium is an essential element for selenoproteins, which play a role in antioxidant defense. It may support the activation of α4-crystallin by helping maintain its structure and function under oxidative stress. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic acid assists in the maintenance of cellular homeostasis and may promote the stabilization and activation of α4-crystallin under stress conditions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to induce heat shock proteins and could therefore activate α4-crystallin by enhancing its chaperone function and preventing protein aggregation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol upregulates the expression of heat shock proteins, which may include α4-crystallin, leading to its activation and increased chaperone efficiency. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG induces the heat shock response by inhibiting Hsp90, which may result in the compensatory upregulation of other heat shock proteins including α4-crystallin, thereby activating its chaperone function. | ||||||