ALDH1A1 Inhibitors

Common ALDH1A1 Inhibitors include, but are not limited to Disulfiram CAS 97-77-8, Citral CAS 5392-40-5, Daidzin CAS 552-66-9, 4-(Dimethylamino)benzaldehyde CAS 100-10-7 and Gossypol CAS 303-45-7.

ALDH1A1 inhibitors belong to a specific chemical class of compounds that are meticulously designed to modulate the activity of the ALDH1A1 enzyme. ALDH1A1, also known as Aldehyde Dehydrogenase 1A1, is a key enzyme involved in the oxidation of aldehydes to corresponding carboxylic acids, playing a significant role in cellular detoxification and metabolism. These inhibitors are carefully crafted molecules engineered to interact with the ALDH1A1 enzyme, influencing its normal catalytic function. Through these interactions, they may impact various cellular processes associated with aldehyde metabolism and cellular detoxification, without directly altering its catalytic site or its involvement in metabolic pathways.

The design of ALDH1A1 inhibitors is grounded in a comprehensive understanding of the structural and functional characteristics of the ALDH1A1 enzyme. Typically developed using advanced chemical synthesis methods and informed by insights from structural biology, these inhibitors are characterized by their ability to selectively bind to ALDH1A1. This selectivity allows for targeted intervention in cellular pathways that rely on the activity of this specific enzyme. Unraveling the intricacies of cellular metabolism, detoxification processes, and aldehyde homeostasis often employ ALDH1A1 inhibitors as valuable tools. The development and utilization of ALDH1A1 inhibitors contribute to advancing our knowledge of the complex interplay between cellular components and metabolic dynamics, providing insights into the fundamental molecular mechanisms that govern cellular detoxification and aldehyde metabolism.