Aldehyde dehydrogenase 1-A1/ALDH1A1 Antibody (B-5): sc-374149

ALDH1A1 Antibody (B-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects ALDH1A1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-ALDH1A1 antibody (B-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ALDH1A1, also known as retinal dehydrogenase 1, plays a crucial role in retinoic acid biosynthesis, a vital signaling molecule involved in embryonic development, cell differentiation, and immune function. ALDH1A1 catalyzes retinaldehyde conversion to retinoic acid, essential for regulating gene expression and maintaining proper cellular functions. ALDH1A1′s importance extends to aldehydes detoxification, which can harm cells if accumulated, contributing to cellular homeostasis and protection against oxidative stress. ALDH1A1 is implicated in various pathological conditions, including cancer, where expression may increase in response to oxidative stress, highlighting potential as a biomarker for tumor metabolism and therapeutic intervention target.

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Aldehyde dehydrogenase 1-A1/ALDH1A1 Antibody (B-5) References:

1. Discovery and development of selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors.  |  Li, B., et al. 2021. Eur J Med Chem. 209: 112940. PMID: 33328099
2. Novel Disulfiram Derivatives as ALDH1a1-Selective Inhibitors.  |  Omran, Z. 2022. Molecules. 27: PMID: 35056791
3. ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism.  |  Yue, H., et al. 2022. Front Oncol. 12: 918778. PMID: 35814382
4. ALDH1A1 Expression Is Enriched in Early-Onset Colorectal Cancers.  |  Venugopal, A., et al. 2022. Gastroenterology. 163: 1679-1681.e1. PMID: 35985512
5. ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression.  |  Lavudi, K., et al. 2023. NPJ Precis Oncol. 7: 66. PMID: 37429899
6. Modification of lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression.  |  Zhang, Z., et al. 2023. iScience. 26: 108142. PMID: 37867947
7. Autism patient-derived SHANK2BY29X mutation affects the development of ALDH1A1 negative dopamine neuron.  |  Lai, W., et al. 2024. Mol Psychiatry. 29: 3180-3194. PMID: 38704506
8. ALDH1A1 promotes immune escape of tumor cells through ZBTB7B-glycolysis pathway.  |  Wang, M., et al. 2024. Cell Death Dis. 15: 568. PMID: 39107297
9. The role of ALDH1A1 in glioblastoma proliferation and invasion.  |  Huang, YK., et al. 2024. Chem Biol Interact. 402: 111202. PMID: 39128802
10. Targeting ALDH1A1 to enhance the efficacy of KRAS-targeted therapy through ferroptosis.  |  Bian, Y., et al. 2024. Redox Biol. 77: 103361. PMID: 39317105

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aldehyde dehydrogenase 1-A1/ALDH1A1 Antibody (B-5) has 29 citations in a variety of scientific publications.

Primary antibodies like Anti-Aldehyde dehydrogenase 1-A1/ALDH1A1 Antibody (B-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aldehyde dehydrogenase 1-A1/ALDH1A1 Antibody (B-5) Specifications

Alternate Product Name: ALDH1A1

Product Clone Name: B-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 105-137

Epitope Target: ALDH1A1

Epitope Species: human

Product Reactivity/Detection: ALDH1A1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 29 citations in various scientific publications

Available Conjugates/Forms for Aldehyde dehydrogenase 1-A1/ALDH1A1 Antibody (B-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Aldehyde dehydrogenase /2/ALDH1A1/2/3/ALDH2 antibody is Aldehyde dehydrogenase /2/ALDH1A1/2/3/ALDH2 Antibody (H-8): sc-166362.