Aldehyde dehydrogenase /2/ALDH1A1/2/3/ALDH2 Antibody (H-8): sc-166362

ALDH1/2 Antibody (H-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects ALDH1/2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ALDH1/2 (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Aldehyde dehydrogenases (ALDHs) play a crucial role in detoxifying aldehydes, converting them into less toxic acids, which is vital for cellular health and metabolism. ALDH1A1, also known as retinal dehydrogenase 1, participates in retinoic acid biosynthesis, a key signaling molecule regulating gene expression essential for embryonic development and cellular differentiation. ALDH1A1 localizes in the cytosol while ALDH2 functions in the mitochondria, highlighting distinct metabolic pathways, with ALDH2 being particularly important in alcohol metabolism. Genetic variation in ALDH2, present in most Caucasians but absent in approximately 50% of Asians, influences alcohol metabolism and associated health risks, including reduced likelihood of developing alcoholism-related liver disease.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aldehyde dehydrogenase /2/ALDH1A1/2/3/ALDH2 Antibody (H-8) has 56 citations in a variety of scientific publications.

Primary antibodies like Anti-Aldehyde dehydrogenase /2/ALDH1A1/2/3/ALDH2 Antibody (H-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aldehyde dehydrogenase /2/ALDH1A1/2/3/ALDH2 Antibody (H-8) Specifications

Alternate Product Name: ALDH1/2

Product Clone Name: H-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 186-270

Epitope Target: ALDH1A1

Epitope Species: human

Product Reactivity/Detection: ALDH1A1, ALDH1A2, ALDH1A3 and ALDH2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 56 citations in various scientific publications

Available Conjugates/Forms for Aldehyde dehydrogenase /2/ALDH1A1/2/3/ALDH2 Antibody (H-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin