ALDH Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram acts as a potent inhibitor of aldehyde dehydrogenase (ALDH), disrupting the enzyme's catalytic activity through covalent modification. This interaction leads to the formation of a stable adduct, effectively blocking the conversion of acetaldehyde to acetic acid. The compound's unique reactivity with thiol groups enhances its selectivity, resulting in altered metabolic pathways. Its kinetic profile reveals a time-dependent inhibition, allowing for nuanced modulation of ALDH activity. | ||||||
Piloty′s Acid | 599-71-3 | sc-205436 sc-205436A | 500 mg 1 g | $20.00 $32.00 | ||
Piloty's Acid functions as a selective inhibitor of aldehyde dehydrogenase (ALDH) by forming a reversible complex with the enzyme's active site. This interaction alters the enzyme's conformation, impacting its ability to process aldehydes. The compound exhibits unique reactivity due to its electrophilic nature, facilitating specific interactions with nucleophilic residues. Its kinetic behavior showcases a competitive inhibition pattern, influencing metabolic flux and substrate availability in cellular pathways. | ||||||
N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide | 142867-52-5 | sc-203441 sc-203441A | 10 mg 50 mg | $408.00 $765.00 | ||
N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide acts as a potent inhibitor of aldehyde dehydrogenase (ALDH) through a distinct mechanism involving covalent modification of key amino acid residues. This compound's sulfonamide group enhances its electrophilicity, promoting selective interactions with nucleophiles in the enzyme's active site. Its unique structural features lead to altered reaction kinetics, significantly affecting the enzyme's catalytic efficiency and substrate turnover in metabolic processes. | ||||||
Cyanamide | 420-04-2 | sc-239592 sc-239592A | 5 g 25 g | $21.00 $77.00 | ||
Cyanamide functions as an aldehyde dehydrogenase (ALDH) inhibitor by engaging in non-covalent interactions with the enzyme's active site. Its unique structure allows for competitive inhibition, where it mimics the enzyme's natural substrates, disrupting normal catalytic activity. The compound's ability to modulate enzyme conformation influences reaction kinetics, leading to a decrease in substrate conversion rates. This dynamic interaction highlights its role in metabolic regulation. | ||||||
Phenylglyoxal | 1075-06-5 | sc-253263 | 5 g | $75.00 | ||
Phenylglyoxal acts as an aldehyde dehydrogenase (ALDH) inhibitor through covalent modification of the enzyme's active site. Its electrophilic carbonyl group forms a stable adduct with nucleophilic residues, effectively altering the enzyme's conformation and inhibiting its activity. This irreversible binding results in a significant reduction in enzymatic turnover, impacting metabolic pathways. The compound's reactivity and specificity underscore its role in modulating cellular processes. | ||||||