AKAP 2 Inhibitors
AKAP 2 inhibitors belong to a class of chemical compounds designed to target and modulate the activity of A-kinase anchoring proteins, specifically AKAP 2. These inhibitors are pivotal in elucidating the role of AKAP 2 in cellular processes and signal transduction. AKAPs, including AKAP 2, are a family of scaffolding proteins found in various subcellular compartments that play a crucial role in organizing signaling complexes involving protein kinases and other regulatory molecules. AKAP 2, also known as gravin, is primarily localized in the plasma membrane and endosomal compartments, where it serves as a critical regulator of cyclic AMP (cAMP)-dependent protein kinase A (PKA) signaling. It accomplishes this by tethering PKA and other signaling molecules in proximity to their downstream targets, thereby facilitating efficient signal transduction.
AKAP 2 inhibitors are designed to disrupt the interactions between AKAP 2 and its binding partners, most notably PKA, leading to the disassembly of signalosomes and perturbation of cAMP-mediated signaling pathways. The development and utilization of these inhibitors have provided valuable insights into the molecular mechanisms governing AKAP 2-associated cellular processes. Additionally, they offer a valuable tool for researchers studying the regulation of cAMP signaling and its impact on various cellular functions.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
A potent inhibitor of protein kinase A (PKA), it can disrupt the interaction of AKAP2 with PKA, thus inhibiting downstream effects mediated by AKAP2-PKA complex formation. | ||||||
Rp-cAMPS | 151837-09-1 | sc-24010 | 1 mg | $203.00 | 37 | |
A cAMP analog that competitively inhibits cAMP-dependent PKA. It can indirectly inhibit AKAP2 functions by preventing PKA activation. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $138.00 $220.00 $972.00 | 47 | |
This compound selectively inhibits PKA, which can reduce the phosphorylation events facilitated by AKAP2-anchored PKA. | ||||||
PKI (14-22) amide (myristoylated) | 201422-03-9 | sc-471154 | 0.5 mg | $135.00 | 2 | |
A synthetic peptide inhibitor of PKA that can inhibit the catalytic subunit of PKA, thus affecting AKAP2's role in localizing PKA activity. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
It can activate adenosine receptors leading to altered cAMP levels and PKA activity, indirectly influencing AKAP2's interactions with PKA. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase that increases cAMP levels, leading to PKA activation. By altering PKA dynamics, it can indirectly modify AKAP2's role. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
An adenylate cyclase inhibitor that can decrease intracellular cAMP and subsequently PKA activity, affecting AKAP2-related signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, which can raise cAMP levels and non-specifically modulate PKA activity, thus indirectly affecting AKAP2. | ||||||
Sp-cAMPS | 93602-66-5 | sc-201571 | 1 mg | $97.00 | 3 | |
A cell-permeable analog of cAMP that is resistant to degradation by phosphodiesterases and can activate PKA, leading to potential changes in AKAP2-mediated signaling. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Although primarily a PKC inhibitor, it can also modulate PKA signaling, thereby indirectly influencing AKAP2's interaction with PKA. | ||||||