AKAP 13 Activators
AKAP 13 Activators encompass a diverse range of compounds that primarily function by modulating cAMP levels within cells, indirectly influencing AKAP 13 activity. Compounds such as Forskolin, (-)-Epinephrine, Isoproterenol, Dopamine, Histamine, free base, PGE2, Adenosine, Salbutamol, Terbutaline, Iloprost, and Cilostazol all contribute to increased cAMP production either through direct activation of adenylate cyclase or via interaction with various G-protein-coupled receptors. The resultant elevation in cAMP levels is critical for the activation of AKAP 13, as this protein is intricately involved in cAMP-dependent signaling pathways. AKAP 13, known for anchoring protein kinase A (PKA) and regulating its signaling, is thus indirectly stimulated by these compounds through their influence on the cAMP pathway. This modulation of cAMP not only affects PKA activity but also influences the broader array of signaling cascades within which AKAP 13 operates, highlighting its role in coordinating multiple signaling events.
Additionally, compounds like Rolipram and Cilostazol, which inhibit phosphodiesterases 4 and 3 respectively, lead to an accumulation of cAMP within cells. This increased concentration of cAMP further enhances the activity of AKAP 13. By maintaining elevated levels of cAMP, these inhibitors potentiate the role of AKAP 13 in organizing and facilitating cAMP-mediated responses, ensuring efficient and targeted signaling. The cumulative effect of these activators showcases the central role of AKAP 13 in mediating and modulating cAMP-dependent cellular processes. Through these diverse yet interconnected mechanisms, AKAP 13 activators underscore the protein's pivotal function in coordinating cellular responses to various stimuli, fundamentally impacting cell signaling and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP enhances AKAP 13 activity, as AKAP 13 is a cAMP-responsive anchoring protein that interacts with protein kinase A (PKA) and regulates its signaling. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
(-)-Epinephrine, through its interaction with G-protein-coupled receptors, leads to increased cAMP production. This activation of the cAMP pathway indirectly stimulates AKAP 13, which is involved in cAMP-mediated signaling processes. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, increases cAMP levels by stimulating adenylate cyclase, thereby indirectly enhancing AKAP 13 activity through the cAMP signaling pathway. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, via dopamine receptors, can influence cAMP production. This modulation of cAMP levels indirectly enhances AKAP 13 activity, as AKAP 13 is involved in cAMP-dependent signaling mechanisms. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, free base, through H2 receptors, increases cAMP levels, indirectly influencing AKAP 13 activity. AKAP 13 interacts with PKA in cAMP-dependent signaling pathways. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2, via EP2 and EP4 receptors, leads to increased cAMP production. This rise in cAMP levels indirectly enhances AKAP 13 activity, as it is involved in cAMP-mediated signaling. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine, through A2A and A2B receptors, increases cAMP levels, thereby indirectly stimulating AKAP 13 activity in cAMP-dependent signaling pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, leading to increased cAMP levels. Elevated cAMP indirectly enhances AKAP 13 activity, as AKAP 13 is involved in organizing PKA within cAMP signaling complexes. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol, a beta-2 adrenergic agonist, increases cAMP production, indirectly enhancing AKAP 13 activity through the cAMP signaling pathway. | ||||||
Iloprost | 78919-13-8 | sc-205349 sc-205349A | 500 µg 1 mg | $155.00 $269.00 | ||
Iloprost, through IP receptors, increases cAMP levels. This elevation in cAMP indirectly enhances AKAP 13 activity, as AKAP 13 is a key component in cAMP-mediated signaling pathways. | ||||||