AKAP 100 Activators
AKAP 100 Activators are a class of chemical compounds that directly or indirectly enhance the functional activity of AKAP 100. AKAP 100, a member of the A-kinase anchor proteins (AKAPs) family, is involved in multiple cellular processes primarily through its ability to bind to and regulate Protein Kinase A (PKA). Hence, compounds that influence the activity of PKA or pathways associated with PKA can indirectly enhance the functional activity of AKAP 100. For example, cAMP and its analog 8-AHA-cAMP, as well as compounds that increase cAMP levels such as Forskolin, Cholera Toxin, Isoproterenol and Epinephrine, can activate PKA, thereby indirectly enhancing the functional activity of AKAP 100.
Other members of the AKAP 100 Activators class, like Phosphatidylserine, H-89 dihydrochloride, E-4031, Iberiotoxin, Okadaic Acid, and Phorbol 12-myristate 13-acetate (PMA), act through distinct pathways to indirectly enhance AKAP 100 activity. Phosphatidylserine, a phospholipid, can enhance AKAP 100 activity by facilitating its localization to the cell membrane. The compounds E-4031 and Iberiotoxin, which block specific ion channels, can enhance AKAP 100's function by influencing its role in ion channel regulation. Okadaic Acid, an inhibitor of protein phosphatases PP1 and PP2A, can prevent the dephosphorylation of proteins involved in the PKA signaling pathway, indirectly enhancing AKAP 100 activity. Finally, PMA, an activator of Protein Kinase C (PKC), can indirectly enhance AKAP 100 activity due to shared downstream targets between PKC and PKA.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP is a second messenger involved in many physiological processes. AKAP 100 is known to bind to PKA, whose activity is regulated by cAMP. An increase in cAMP levels can activate PKA, which in turn can enhance the functional activity of AKAP 100. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a plant-derived compound that elevates cellular cAMP levels by activating adenylate cyclase. As AKAP 100 is involved in PKA signaling, an increase in cAMP levels can enhance the functional activity of AKAP 100 through PKA activation. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
Phosphatidylserine is a phospholipid component of cell membranes. It is known to bind to AKAP 100, thus potentially enhancing the functional activity of AKAP 100 by facilitating its localization to the cell membrane. | ||||||
8-(6-Aminohexyl)aminoadenosine 3′:5′-cyclic monophosphate | 39824-30-1 | sc-214411 | 25 mg | $390.00 | ||
8-AHA-cAMP is a cell-permeable cAMP analog known to activate PKA. An increase in PKA activity can enhance the functional activity of AKAP 100, which is known to bind to PKA. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, leading to PKA activation. This can enhance the functional activity of AKAP 100 through its involvement in PKA signaling. | ||||||
Iberiotoxin | 129203-60-7 | sc-3585 sc-3585A | 10 µg 100 µg | $275.00 $500.00 | 16 | |
Iberiotoxin is a potent and selective blocker of the large conductance Ca2+-activated K+ channel. As AKAP 100 is known to regulate ion channels through its association with PKA, the action of Iberiotoxin can enhance the functional activity of AKAP 100. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). By inhibiting these phosphatases, it can prevent the dephosphorylation of proteins involved in the PKA signaling pathway, indirectly enhancing the functional activity of AKAP 100. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). As PKC and PKA (which is associated with AKAP 100) share several downstream targets, the activation of PKC by PMA can indirectly enhance the functional activity of AKAP 100. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine is a hormone and neurotransmitter that increases cAMP levels, leading to PKA activation. This can enhance the functional activity of AKAP 100 through its involvement in PKA signaling. | ||||||