AIFL Activators
Apoptosis Inducing Factor Mitochondria Associated 3 (AIFM3) would be a member of the apoptosis-inducing factor (AIF) family characterized by its role in the intrinsic pathway of apoptosis. AIF family members are generally mitochondrial flavoproteins that, upon apoptotic stimuli, translocate from the mitochondria to the nucleus to facilitate chromatin condensation and DNA fragmentation, hallmarks of programmed cell death.
AIFM3, if it were to exist, would likely share structural domains with other AIF proteins, such as a flavin adenine dinucleotide (FAD)-binding domain, which is critical for their oxidoreductase activity, and a C-terminal domain that could mediate its binding to DNA and chromatin. The protein might participate in redox reactions within the mitochondria under normal physiological conditions, contributing to the maintenance of cellular redox homeostasis.Upon apoptotic signals, AIFM3 would likely be released from the mitochondria into the cytosol and subsequently translocate to the nucleus. This release could be mediated by the permeabilization of the mitochondrial outer membrane, a process often regulated by pro-apoptotic members of the Bcl-2 family. In the nucleus, AIFM3 would induce DNA fragmentation, either by direct nuclease activity or by recruiting other DNA-degrading enzymes, leading to the controlled disassembly of the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A inhibits mitochondrial permeability transition, potentially influencing mitochondrial proteins like AIFM3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Known for its anti-oxidant properties, Resveratrol can influence mitochondrial function and apoptosis, potentially impacting AIFM3. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects numerous signaling pathways, including those related to apoptosis, which might impact AIFM3. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
As a drug that influences mitochondrial metabolism, Metformin could indirectly affect AIFM3. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
An antioxidant that can influence mitochondrial function and cellular redox status, potentially impacting AIFM3. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, EGCG can influence apoptosis and mitochondrial pathways, possibly affecting AIFM3. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
As an antioxidant, Vitamin E can affect mitochondrial function and oxidative stress, potentially impacting AIFM3. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Involved in mitochondrial energy processes, Coenzyme Q10 might indirectly influence AIFM3. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
A bile acid that helps in reducing ER stress and may influence mitochondrial functions, possibly impacting AIFM3. | ||||||
ABT-199 | 1257044-40-8 | sc-472284 sc-472284A sc-472284B sc-472284C sc-472284D | 1 mg 5 mg 10 mg 100 mg 3 g | $118.00 $337.00 $520.00 $832.00 $1632.00 | 10 | |
By influencing apoptotic pathways, Bcl-2 inhibitors might indirectly affect AIFM3 activity. | ||||||