AI480653 Inhibitors
Chemical inhibitors of AI480653 can modulate its activity through various molecular pathways by targeting specific enzymes and kinases involved in its regulation. Staurosporine, as a general kinase inhibitor, can inhibit a wide range of protein kinases that may phosphorylate AI480653, a process often essential for its activation or function. Similarly, Wortmannin and LY294002 specifically inhibit phosphoinositide 3-kinases (PI3K), which are upstream regulators of the AKT signaling pathway. Inhibition of this pathway by either chemical can impact AI480653 if it operates downstream of PI3K/AKT, either directly or indirectly. U0126 and PD98059 target the MAPK/ERK pathway by inhibiting MEK1/2, thereby potentially affecting AI480653 if it relies on ERK-mediated phosphorylation for its activity. SB203580's inhibition of p38 MAP kinase and SP600125's inhibition of c-Jun N-terminal kinase (JNK) can likewise alter AI480653's function if it is involved in signaling cascades that are mediated by these kinases.
Additionally, Rapamycin's binding to mTOR can disrupt the mTORC1 complex, which is a central node in cell growth and metabolism, possibly affecting AI480653 if it is regulated by mTOR signaling. PP2, by inhibiting Src family tyrosine kinases, and Dasatinib, as a broad-spectrum tyrosine kinase inhibitor, can alter signaling pathways that involve tyrosine phosphorylation, which can influence AI480653's activity if it is a downstream target. Y-27632, a selective inhibitor of Rho-associated protein kinase (ROCK), can modify the function of AI480653 if it is modulated by the Rho/ROCK pathway. Lastly, Bortezomib's mechanism of proteasome inhibition can lead to the accumulation of protein substrates, including potentially AI480653, if it is subjected to regulation by proteasomal degradation. The interplay of these inhibitors on AI480653's function underscores the complexity and integration of cellular signaling pathways affecting the protein's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. Inhibition of these kinases by staurosporine can lead to the functional inhibition of AI480653 if the protein's activity is dependent on phosphorylation by any of these kinases. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of phosphoinositide 3-kinases. By inhibiting PI3K, wortmannin can inhibit downstream AKT signaling which may be required for the activity of AI480653, leading to its inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2 which blocks MAPK/ERK pathway. As ERK is often involved in phosphorylation of proteins, the inhibition of this pathway by U0126 can inhibit the function of AI480653 if it requires ERK-mediated phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor, which similarly to Wortmannin, can inhibit the PI3K/AKT pathway. LY294002's inhibition of this pathway can functionally inhibit AI480653 if the protein operates downstream of PI3K/AKT. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to mTOR, inhibiting the mTORC1 complex. Inhibition of mTOR can lead to a decrease in protein synthesis and can functionally inhibit AI480653 if it is regulated by mTOR signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which in turn inhibits ERK activation. By preventing the activation of ERK, PD98059 can functionally inhibit AI480653 if it relies on the MEK/ERK pathway for its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor. Inhibition of p38 MAPK can functionally inhibit AI480653 if the protein's activity is mediated through p38 MAPK signaling pathways. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. Src kinases are involved in various signaling pathways, and inhibiting them with PP2 can lead to functional inhibition of AI480653 if it is a downstream effector. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). JNK is implicated in various cellular processes, and inhibition by SP600125 can lead to functional inhibition of AI480653 if the protein is a part of JNK signaling. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor. By inhibiting tyrosine kinases, Dasatinib can functionally inhibit AI480653 if the protein requires tyrosine kinase activity for its function. | ||||||