AGA Activators
AGA Activators are a diverse class of chemical compounds that influence various cellular signaling pathways, leading to the enhanced functional activity of AGA. Phorbol 12-myristate 13-acetate (PMA) and Forskolin represent compounds that activate PKC and adenylyl cyclase, respectively. PMA mimics the physiological activator diacylglycerol, engaging with and activating PKC, which then could phosphorylate AGA or proteins that modulate AGA's activity, leading to an increase in AGA's enzymatic function. Forskolin raises intracellular cAMP levels, which activates PKA, influencing AGA by phosphorylation of AGA itself or regulatory components that can increase its catalytic efficiency.
Calcium ionophores like Ionomycin and A23187 raise intracellular calcium, which activates calcium-dependent protein kinases that are capable of enhancing AGA's activity. This could result from direct phosphorylation of AGA or by modification of proteins within AGA-associated signaling complexes. Inhibitors of protein phosphatases such as Okadaic Acid and Calyculin A increase the phosphorylation levels of cellular proteins, including AGA or its interactors, thereby indirectly enhancing AGA activity. Compounds like Staurosporine and Bisindolylmaleimide I, despite being kinase inhibitors, can indirectly lead to the enhancement of AGA activity by modulating the activity ofspecific kinases or altering the balance of signaling pathways that control AGA function. Staurosporine, at low doses, selectively activates certain PKC isoforms that could enhance AGA activity. Bisindolylmaleimide I, though a PKC inhibitor, may result in compensatory activation of alternative pathways that lead to AGA activation.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that directly activates protein kinase C (PKC). PKC activation enhances AGA by phosphorylating it or associated proteins, which can alter its substrate affinity or cellular localization. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which can activate calcium-dependent protein kinases. These kinases may then phosphorylate AGA or its interacting partners, increasing AGA's enzymatic activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cyclic AMP (cAMP) levels. Elevated cAMP activates PKA, which can phosphorylate AGA or regulatory proteins that control AGA's activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium concentration, similar to Ionomycin, indirectly leading to the activation of AGA through calcium-sensitive pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is an inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins. This can indirectly enhance AGA activity by preventing dephosphorylation of AGA or related proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to a rise in cytosolic calcium levels and subsequent activation of calcium-dependent kinases that can enhance AGA activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A, like Okadaic Acid, is a potent inhibitor of protein phosphatases. This leads to a sustained phosphorylated state of proteins, potentially enhancing AGA activity by similar mechanisms. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I specifically inhibits PKC. This could lead to a shift in cell signaling pathways that compensate by activating AGA through alternative kinases or pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs). This activation can indirectly lead to the phosphorylation and enhancement of AGA activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor but at low doses selectively activates certain PKC isoforms. This selective activation can enhance AGA activity through PKC-mediated pathways. | ||||||