Ag2 Inhibitors
Ag2 inhibitors encompass a variety of chemical compounds that indirectly suppress the functional activity of Ag2 by targeting signaling pathways and enzymatic activities that regulate or influence Ag2 function. The inhibitors function at different levels of cellular signaling cascades, ranging from receptor tyrosine kinases to key intracellular kinases that propagate cellular responses. For example, the inhibition of JAK2 by AG-490 disrupts the JAK/STAT signaling pathway, which may be essential for the regulation of Ag2. This disruption leads to decreased transcriptional activation of genes downstream of STAT that may be crucial for the expression or activity of Ag2. In this way, AG-490 can indirectly suppress Ag2 activity by interfering with its regulatory mechanisms.
Similarly, inhibitors like LY294002 and Wortmannin target the PI3K/AKT signaling pathway, which is a critical pathway for cell survival, growth, and proliferation. Ag2, if it is a protein or factor involved in these processes, would likely be affected by the inhibition of PI3K, as AKT phosphorylation and subsequent signaling are crucial for the functional modulation of many cellular proteins.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AG-490 | 133550-30-8 | sc-202046C sc-202046A sc-202046B sc-202046 | 5 mg 50 mg 25 mg 10 mg | $82.00 $323.00 $219.00 $85.00 | 35 | |
AG-490 is a tyrosine kinase inhibitor that specifically targets the JAK2/STAT pathway. By inhibiting JAK2, AG-490 prevents the phosphorylation and subsequent activation of STAT proteins which are crucial for various gene expressions. This inhibition can reduce the functional activity of Ag2, as Ag2 is involved in the downstream signaling events that are mediated by STAT proteins. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K). It blocks the activation of PI3K, leading to the suppression of the AKT signaling pathway. Given that Ag2 activity is modulated by AKT-mediated signaling, LY294002 can decrease Ag2's functional activity by preventing its AKT-dependent activation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, enzymes in the MAPK/ERK pathway. Inhibition of MEK1/2 prevents the activation of ERK, which may be necessary for the phosphorylation and activation of substrates involved in Ag2 function. Thus, blocking MEK1/2 can indirectly inhibit Ag2 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 specifically inhibits p38 MAP kinase, which is involved in the response to stress stimuli and cytokines. Ag2 may be regulated by p38-mediated signaling events, and the inhibition of p38 MAPK by SB203580 could suppress the functional activity of Ag2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that impedes the MAPK/ERK pathway by preventing the activation of MEK, which in turn inhibits ERK activation. Since Ag2 activity relies on signals propagated through the ERK pathway, PD98059 can reduce its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that disrupts the mTORC1 complex, leading to inhibition of downstream signaling required for cell growth and proliferation. Since Ag2 is implicated in cell growth processes, rapamycin can indirectly inhibit Ag2 by shutting down these mTORC1-dependent pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, blocking the PI3K/AKT signaling pathway. This action prevents downstream effects that may include the activation of Ag2. By inhibiting PI3K, wortmannin can reduce the functional activity of Ag2. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of c-Jun N-terminal kinase (JNK), which is involved in the regulation of apoptosis and cell proliferation. The inhibition of JNK can influence cellular processes that regulate the function of Ag2, thus indirectly decreasing its activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective Src family tyrosine kinase inhibitor. As Src kinases can modulate various signaling pathways including those that regulate Ag2, inhibition of Src by PP2 can downregulate Ag2's functional activity. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an EGFR tyrosine kinase inhibitor. By blocking EGFR signaling, it can affect downstream pathways that involve Ag2 function, leading to reduced activity of Ag2. | ||||||