advillin Inhibitors
Advillin inhibitors represent a specific class of molecules that modulate the activity of advillin, a member of the villin superfamily of actin-binding proteins. Advillin is primarily involved in cytoskeletal organization, particularly in structures related to sensory neurons. It plays a critical role in shaping the dynamic assembly and disassembly of actin filaments, a vital component of cellular scaffolding. By influencing these structural changes, advillin is integral to various cellular processes, such as cell motility, morphological changes, and signal transduction pathways. The inhibitors of advillin typically function by interacting with the protein's actin-binding domains, thereby altering its ability to effectively regulate actin dynamics. The inhibition of advillin can lead to profound effects on cellular mechanics, often resulting in altered cytoskeletal architecture and impaired cellular mobility.
In the context of research into cytoskeletal behavior, advillin inhibitors are studied for their ability to modulate cellular structure and activity. These inhibitors offer a window into the role of actin filaments and their associated proteins in cellular function. Disruption of advillin's regulatory role in actin assembly may reveal insights into the broader mechanisms of cellular organization, membrane dynamics, and intracellular signaling. Given the importance of the cytoskeleton in maintaining cellular integrity and its involvement in numerous intracellular pathways, the study of advillin inhibitors is valuable for understanding how protein-protein interactions govern the structural and functional properties of cells. These inhibitors can also be valuable for studying how cells respond to mechanical stress and other environmental stimuli, given their influence on actin dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to the DNA at the transcription initiation complex, preventing elongation of the mRNA strand, thus directly downregulating transcription of the advillin gene. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide disrupts protein synthesis by inhibiting the peptidyl transferase activity of the ribosome, leading to a decrease in the synthesis of the advillin protein. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin specifically binds to mTORC1, leading to a reduced phosphorylation of downstream targets that are crucial for cap-dependent translation initiation, potentially resulting in decreased synthesis of advillin. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 inhibits the proteasome, leading to an accumulation of misfolded proteins, which may trigger a cellular stress response that could downregulate the transcription of certain genes, including advillin. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound induces DNA demethylation by inhibiting DNA methyltransferase, which could lead to the reactivation of silenced genes or, conversely, the suppression of actively transcribed genes such as advillin. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases, which can result in hyperacetylated chromatin and potentially reduce the transcriptional activity of genes like advillin. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can bind to retinoic acid receptors, which may alter the transcription of genes involved in cell differentiation and apoptosis, potentially reducing advillin expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine's interference with lysosomal acidification can lead to a cascade of changes in cellular processing and signaling, potentially resulting in the reduced expression of genes such as advillin. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $440.00 $900.00 $1400.00 $2502.00 | ||
Emetine binds to the 40S ribosomal subunit, inhibiting protein chain elongation, which can lead to a decrease in the production of proteins, including advillin. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 competes with acetyl-lysine for binding to the bromodomain and extra-terminal (BET) family of proteins, potentially leading to decreased expression of target genes including advillin. | ||||||