ADAMTS-19 Inhibitors
ADAMTS-19 Inhibitors constitute a class of chemicals that function by curtailing the activity of ADAMTS-19, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. These inhibitors function through distinct mechanisms to impede the activation and function of ADAMTS-19. For instance, Batimastat, Marimastat, GM6001, Prinomastat, BB-94, Ilomastat, ARP 100, Tanomastat, PD166793, RS-130830, and UK-356618 act directly on ADAMTS-19 by inhibiting its proteolytic activity. These inhibitors prevent the degradation of the extracellular matrix (ECM), thereby affecting the ability of ADAMTS-19 to process its substrates.
TAPI-0, on the other hand, inhibits ADAMTS-19 indirectly. It is an inhibitor of the tumor necrosis factor-alpha converting enzyme (TACE), which is associated with the processing of ADAMTS-19. By inhibiting TACE, TAPI-0 can indirectly inhibit the activation and function of ADAMTS-19. Overall, each of these inhibitors ultimately leads to the functional inhibition of ADAMTS-19 by either directly inhibiting its proteolytic activity, which is vital forits function in the degradation of the extracellular matrix and processing of substrates, or by indirectly impairing its activation and function through the inhibition of associated enzymes like TACE.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
A potent matrix metalloproteinase (MMP) inhibitor that can inhibit the proteolytic activity of ADAMTS-19. By interfering with the MMP activity, it reduces the extracellular matrix degradation, affecting ADAMTS-19's ability to process its substrates. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
A broad spectrum MMP inhibitor that can inhibit ADAMTS-19's proteolytic activity, thereby reducing the degradation of the extracellular matrix and potentially affecting the ability of ADAMTS-19 to process its substrates. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
An inhibitor of MMPs that can inhibit the proteolytic activity of ADAMTS-19, reducing its ability to degrade the extracellular matrix and process substrates. | ||||||
Prinomastat | 192329-42-3 | sc-507449 | 5 mg | $190.00 | ||
A synthetic MMP inhibitor that can inhibit the proteolytic activity of ADAMTS-19, reducing its ability to degrade the extracellular matrix and thus affecting its substrate processing activity. | ||||||
ARP 100 | 704888-90-4 | sc-203522 | 5 mg | $208.00 | 26 | |
A highly selective MMP-2 inhibitor that can inhibit the proteolytic activity of ADAMTS-19, reducing its ability to degrade the extracellular matrix and thus affecting its substrate processing activity. | ||||||
PD166793 | 199850-67-4 | sc-202709 | 5 mg | $150.00 | 6 | |
A non-peptidic, synthetic inhibitor of MMPs that can inhibit the proteolytic activity of ADAMTS-19, reducing its ability to degrade the extracellular matrix and thus affecting its substrate processing activity. | ||||||
UK 356618 | 230961-08-7 | sc-361392 sc-361392A | 5 mg 25 mg | $117.00 $444.00 | 2 | |
A potent and selective inhibitor of MMP-3, MMP-12, MMP-13, and MMP-9 that can inhibit the proteolytic activity of ADAMTS-19, reducing its ability to degrade the extracellular matrix and thus affecting its substrate processing activity. | ||||||