Molecular structure of UK 356618, CAS Number: 230961-08-7
UK 356618 (CAS 230961-08-7)
See product citations (2)
Alternate Names:
(2R)-N1-[(1S)-2,2-Dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]-2-{3-[(3-methyl-4-phenyl)-phenyl]propyl}-(N4-hydroxy)butanediamide
Application:
UK 356618 is a selective and potent inhibitor of MMP-3
CAS Number:
230961-08-7
Purity:
≥98%
Molecular Weight:
557.72
Molecular Formula:
C34H43N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
UK 356618 is a selective and potent inhibitor of MMP-3 that shows selectivity over a range of MMPs. In in vitro studies, UK 356618 has shown inhibitory effects on IL-6-induced migration of NCI H446 small cell lung cancer (SCLC) cells, with an inhibition concentration of 73 nM. When compared to MMP-3, UK 356618 exhibits lower potency against MMP-1, MMP-2, MMP-9, MMP-13, and MMP-14.
UK 356618 (CAS 230961-08-7) References
- Interleukin 6 trigged ataxia-telangiectasia mutated activation facilitates lung cancer metastasis via MMP-3/MMP-13 up-regulation. | Jiang, YN., et al. 2015. Oncotarget. 6: 40719-33. PMID: 26528698
- Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke. | Hafez, S., et al. 2016. Stroke. 47: 843-51. PMID: 26839355
- The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells. | Abe, H., et al. 2016. Biochem Biophys Res Commun. 479: 907-912. PMID: 27678293
- Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells. | Wang, J., et al. 2017. Oncotarget. 8: 81880-81891. PMID: 29137230
- Endothelial stromelysin1 regulation by the forkhead box-O transcription factors is crucial in the exudative phase of acute lung injury. | Artham, S., et al. 2019. Pharmacol Res. 141: 249-263. PMID: 30611853
- Effects of matrix metalloproteinase inhibitors on N-methyl-D-aspartate receptor and contribute to long-term potentiation in the anterior cingulate cortex of adult mice. | Matsuura, T., et al. 2019. Mol Pain. 15: 1744806919842958. PMID: 30900509
- Long-term plasticity of inhibitory synapses in the hippocampus and spatial learning depends on matrix metalloproteinase 3. | Wiera, G., et al. 2021. Cell Mol Life Sci. 78: 2279-2298. PMID: 32959071
- Elucidating cancer-vascular paracrine signaling using a human organotypic breast cancer cell extravasation model. | Humayun, M., et al. 2021. Biomaterials. 270: 120640. PMID: 33592387
- Interleukin-1β-induced matrix metalloproteinase-3 via ERK1/2 pathway to promote mesenchymal stem cell migration. | Chang, CH., et al. 2021. PLoS One. 16: e0252163. PMID: 34019587
- Profiling of Multiple Matrix Metalloproteinases Activities in the Progression of Osteosarcoma by Peptide Microarray-Based Fluorescence Assay on Polymer Brush-Coated Zinc Oxide Nanorod Substrate. | Wang, Z., et al. 2023. Methods Mol Biol. 2578: 161-175. PMID: 36152286
- Osteoblastic STAT3 Is Crucial for Orthodontic Force Driving Alveolar Bone Remodeling and Tooth Movement. | Gong, X., et al. 2023. J Bone Miner Res. 38: 214-227. PMID: 36370067
- Interleukin-1β triggers matrix metalloprotease-3 expression through p65/RelA activation in melanoma cells. | Nunomura, J., et al. 2022. PLoS One. 17: e0278220. PMID: 36445856
- Cerebral microvascular matrix metalloproteinase-3 (MMP3) contributes to vascular injury after stroke in female diabetic rats. | Abdul, Y., et al. 2023. Neurochem Int. 162: 105462. PMID: 36509234
Inhibitor of:
ADAMTS-19, FAPα, MBLAC2, MMP-10, MMP-2, MMP-3, MMP-9, and Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UK 356618, 5 mg | sc-361392 | 5 mg | $115.00 | |||
UK 356618, 25 mg | sc-361392A | 25 mg | $435.00 |