ADAM23 Activators
ADAM23 activators encompass a variety of chemical compounds that can indirectly amplify the functional activity of ADAM23 by modulating cellular signaling pathways and proteolytic processes. MnCl2 serves as a crucial co-factor, potentially enhancing the metalloprotease domain's catalytic activity, which is central to ADAM23's function in modulating cell adhesion and signaling. Similarly, the presence of Batimastat and Galardin, both metalloprotease inhibitors, might indirectly augment ADAM23's activity by reducing the proteolytic breakdown of shared substrates, thus preserving the structural integrity of cell adhesion complexes that ADAM23 regulates. ADAM23 activators are a group of chemical compounds that indirectly enhance the functional activity of ADAM23, a protein implicated in cell adhesion and signaling within the nervous system.
Manganese(II) chloride (MnCl2) could boost ADAM23's metalloprotease activity by supplying the essential divalent cations for the protein's proteolytic function, directly impacting cell-matrix interactions. Broad-spectrum matrix metalloprotease inhibitors like Batimastat and Galardin may indirectly increase ADAM23 activity by preventing the degradation of proteins that interact with or are substrates of ADAM23, thereby facilitating its role in cell adhesion. N-Acetylcysteine, by elevating intracellular glutathione, could protect ADAM23 against oxidative inactivation, while PMA, acting as a protein kinase C (PKC) activator, might promote phosphorylation events that enhance ADAM23's integration in cellular signaling. Ionomycin, through increasing intracellular calcium levels, and H-89, by modulating protein kinase A pathways, could influence ADAM23's conformation or interaction with binding partners, consequently enhancing its activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese(II) chloride may enhance ADAM23's metalloprotease activity by providing essential divalent cations necessary for the proteolytic function of ADAM metalloproteases. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetylcysteine can raise cellular glutathione levels, which may protect ADAM23 from oxidative inactivation, thus maintaining its functional activity in the cell. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a PKC activator which could enhance ADAM23 activity by influencing the phosphorylation of cytoplasmic domain that could affect its shedding or interaction with intracellular partners. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
As a calcium ionophore, ionomycin increases intracellular Ca2+ concentration, potentially enhancing ADAM23 activity through Ca2+-dependent proteolytic activation or modulation of adhesion processes. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a protein kinase A inhibitor that may lead to changes in cell adhesion and signaling pathways, indirectly enhancing the function of ADAM23 through altering its interaction with other proteins. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $121.00 $456.00 | 28 | |
Calpeptin, a calpain inhibitor, could preserve the function of ADAM23 by preventing its degradation or functional modulation by calpain, thus maintaining its activity in the cell. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Galardin is another broad-spectrum metalloprotease inhibitor which may indirectly enhance ADAM23 activity by inhibiting competing proteases that degrade proteins within the same substrates or pathways. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT is a γ-secretase inhibitor which may impact ADAM23 activity by modulating cellular processes involving proteolytic processing, potentially affecting the substrates and pathways ADAM23 is part of. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates cAMP which can lead to activation of PKA and subsequent phosphorylation events that may enhance ADAM23's role in cell signaling and adhesion. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
As a major excitatory neurotransmitter, glutamate may enhance ADAM23 activity by modulating neuronal signaling and synaptic interactions where ADAM23 is potentially involved. | ||||||