ACTR-IA Activators
ACTR-IA, also known as ACVR1 or activin A receptor type I, is a protein that plays a critical role in the transduction of certain growth factors' signals inside cells. This protein is part of the TGF-beta superfamily of receptors, which are integral to a variety of cellular processes including proliferation, differentiation, and apoptosis. The activin A receptor type I binds to ligands such as activin and bone morphogenetic proteins (BMPs), which are involved in the regulation of embryonic development and tissue homeostasis. In the intricate web of cellular signaling, ACTR-IA acts as a serine/threonine kinase, which phosphorylates specific proteins called Smads, triggering a cascade of events that ultimately lead to changes in gene expression.
Understanding how to upregulate the expression of ACTR-IA can provide insights into the regulation of these important biological pathways. Several compounds have been identified that can potentially increase the production of the ACTR-IA protein. For instance, retinoic acid, a metabolite of vitamin A, is known for its ability to stimulate gene expression by activating nuclear receptors. This action can result in the enhanced transcription of genes like ACTR-IA. Similarly, forskolin, by elevating intracellular cyclic AMP levels, can activate a signaling cascade that leads to the activation of protein kinase A and subsequent transcriptional activation of target genes, potentially including ACTR-IA. Additionally, compounds such as BMP-2 are naturally occurring proteins that can directly stimulate the transcription of their receptors, such as ACTR-IA, thereby increasing the receptor's own expression. These activators work through diverse mechanisms to ensure that the necessary signals are relayed within the cell to maintain normal cellular functions and uphold the delicate balance required for cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, through its interaction with retinoid receptors, may upregulate ACTR-IA transcription by promoting the differentiation of cells that preferentially express this receptor in bovine tissue. This effect is likely mediated by the retinoic acid receptor’s ability to bind to retinoid response elements in the promoter region of the ACTR-IA gene. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can stimulate the synthesis of cyclic AMP, which may lead to an increase in ACTR-IA expression by triggering protein kinase A (PKA) signaling cascades. This can result in the phosphorylation of transcription factors that specifically target the ACTR-IA gene's promoter sequence in bovine cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone may upregulate ACTR-IA expression through its action as a synthetic glucocorticoid. It can activate glucocorticoid response elements in the genome, which may include those near or within the ACTR-IA gene locus, leading to enhanced transcription in cattle. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can stimulate the Wnt/beta-catenin pathway, which may result in the increased transcription of downstream target genes, including ACTR-IA. This induction could be due to the stabilization of beta-catenin, which translocates to the nucleus and associates with T-cell factor/lymphoid enhancer-binding factor to initiate transcription in bovine cells. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, as a potent histone deacetylase inhibitor, can increase the acetylation of histones associated with the chromatin of the ACTR-IA gene. The hyperacetylated state of histones is linked to an open chromatin structure, leading to an elevated transcriptional initiation and upregulation of ACTR-IA in bovine cells. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can induce ACTR-IA expression by incorporation into DNA, where it inhibits DNA methyltransferase, leading to reduced methylation of the ACTR-IA gene promoter. This hypomethylation state tends to be associated with active gene expression and could result in increased levels of ACTR-IA mRNA in bovine cells. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB 431542 specifically inhibits the kinase activity of the TGF-beta type I receptor ALK5, which may lead to an upswing in ACTR-IA expression by preventing the negative feedback loop typically enforced by TGF-beta signaling on its receptors in cattle. | ||||||