ACTR-IA Antibody (Y0311): sc-73676

ACTR-IA Antibody (Y0311) is a mouse monoclonal IgG1 antibody that detects the ACTR-IA protein of human origin by western blotting (WB) and immunofluorescence (IF). Anti-ACTR-IA antibody (Y0311) is available as the non-conjugated format. ACTR-IA protein, also known as Activin receptor-like kinase 2 (ALK2), plays a crucial role in the TGFβ signaling pathway, which is essential for various biological processes, including cell differentiation, proliferation, and apoptosis. ACTR-IA (ALK2) is primarily located in the placenta, heart, and skeletal muscle, where ACTR-IA (ALK2) facilitates the phosphorylation and activation of Smad transcription factors, specifically Smad1, Smad5, and Smad8. Proper functioning of ACTR-IA is vital for normal cardiac development, as ACTR-IA (ALK2) is implicated in the epithelial-mesenchymal transition during heart formation. Furthermore, mutations in the ACTR-IA gene have been associated with Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by abnormal bone growth. Using anti-ACTR-IA antibody (Y0311) in research can provide valuable insights into the role of this receptor in developmental biology and disease mechanisms.

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ACTR-IA Antibody (Y0311) References:

1. The bone morphogenetic protein type Ib receptor is a major mediator of glial differentiation and cell survival in adult hippocampal progenitor cell culture.  |  Brederlau, A., et al. 2004. Mol Biol Cell. 15: 3863-75. PMID: 15194807
2. Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells.  |  Kaartinen, V., et al. 2004. Development. 131: 3481-90. PMID: 15226263
3. BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo.  |  de Sousa Lopes, SM., et al. 2004. Genes Dev. 18: 1838-49. PMID: 15289457
4. Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.  |  Besser, D. 2004. J Biol Chem. 279: 45076-84. PMID: 15308665
5. Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation.  |  Desgrosellier, JS., et al. 2005. Dev Biol. 280: 201-10. PMID: 15766759
6. Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart.  |  Wang, J., et al. 2005. Dev Biol. 286: 299-310. PMID: 16140292
7. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva.  |  Shore, EM., et al. 2006. Nat Genet. 38: 525-7. PMID: 16642017
8. BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis.  |  Komatsu, Y., et al. 2007. Dev Dyn. 236: 512-7. PMID: 17117439
9. The ACVR1 617G>A mutation is also recurrent in three Japanese patients with fibrodysplasia ossificans progressiva.  |  Nakajima, M., et al. 2007. J Hum Genet. 52: 473-475. PMID: 17351709