ACSBG2 Activators

acyl-CoA synthetase bubblegum family member 2 (ACSBG2) engage with the protein through a variety of mechanisms, primarily involving the activation of peroxisome proliferator-activated receptors (PPARs) which are nuclear receptor proteins that function as transcription factors regulating the expression of genes. ACSBG2, being a part of lipid metabolism pathways, is influenced by the activation of these receptors. Oleoylethanolamide, Bezafibrate, Fenofibrate, WY-14643, Clofibrate, and Gemfibrozil activate PPAR-α, a receptor that when stimulated, enhances fatty acid oxidation and energy expenditure, processes in which ACSBG2 plays a significant role. For instance, Bezafibrate and Fenofibrate, by activating PPAR-α, increase the lipid metabolism pathways activity, consequently leading to a higher turnover of lipids where ACSBG2 is involved. WY-14643, as a selective agonist for PPAR-α, potentiates lipid catabolism which implicates an enhancement in the activation of ACSBG2's role in lipid handling.

Compounds like L-165041 and GW 501516 target the PPAR-β/δ, and although ACSBG2 is more closely related to PPAR-α, the activation of PPAR-β/δ also plays a part in the regulation of lipid metabolism, which could influence the activity of ACSBG2. Additionally, Eicosapentaenoic Acid, an omega-3 fatty acid, activates PPAR-α, which would lead to an increase in the activity of ACSBG2 in the metabolism of fatty acids. Palmitoylethanolamide, while primarily recognized for its anti-inflammatory properties, also interacts with PPAR-α, which suggests an increase in the activity of ACSBG2 in lipid metabolism. Pioglitazone and Rosiglitazone, both of which are PPAR-γ agonists, by promoting alterations in lipid metabolism, can indirectly influence the activation of ACSBG2. Through these multifaceted interactions with PPARs, these chemical activators modulate the activity of ACSBG2 in various pathways related to lipid metabolism.