ACOT12 Activators
The chemical class referred to as ACOT12 Activators encompasses a range of compounds known for their ability to upregulate the expression or activity of Acyl-CoA thioesterase 12 (ACOT12), an enzyme involved in lipid metabolism. These activators, through various biochemical mechanisms, enhance the catalytic efficiency of ACOT12, leading to increased hydrolysis of acyl-CoAs into free fatty acids and coenzyme A. This process is crucial in maintaining the balance of fatty acid metabolism within cells. The diversity in the structure and function of ACOT12 activators reflects the complexity of lipid metabolic pathways and the intricate regulatory mechanisms governing them. Some activators might bind directly to the ACOT12 enzyme, altering its conformation in a way that enhances its activity. Others may work indirectly, modulating the expression of the ACOT12 gene by influencing transcription factors or altering epigenetic markers associated with the gene.
The significance of ACOT12 activators lies in their role in regulating cellular lipid levels, which is a key aspect of maintaining cellular homeostasis. By influencing ACOT12 activity, these compounds can affect the balance between free fatty acids and their CoA esters, pivotal components in various metabolic processes. This balance is essential for numerous cellular functions, including energy production, membrane synthesis, and signaling. The study of ACOT12 activators provides valuable insights into the molecular mechanisms of lipid metabolism, highlighting the interplay between enzymes, substrates, and regulatory molecules. Research in this area delves into understanding how different activators interact with ACOT12, the structural basis of their action, and the downstream effects of altered ACOT12 activity on cellular metabolism. This exploration contributes to a broader understanding of metabolic regulation at the molecular level, offering perspectives on the dynamic nature of enzyme regulation and the diversity of molecules capable of modulating enzyme activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could potentially upregulate ACOT12 by affecting transcription factors or enhancer elements associated with the ACOT12 gene. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin might increase ACOT12 expression by elevating cAMP levels, potentially activating protein kinase A (PKA) and influencing transcription factors that regulate ACOT12. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could enhance ACOT12 expression as part of its role in modulating sirtuins and AMPK pathways, both implicated in metabolic regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could upregulate ACOT12 by influencing NF-κB signaling pathways, which are involved in the regulation of various genes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG might upregulate ACOT12 through its influence on cellular oxidative stress response and lipid metabolism pathways. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
β-Nicotinamide mononucleotide could enhance ACOT12 expression by altering NAD+ levels and affecting sirtuin signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane could upregulate ACOT12 through its effects on the NRF2 pathway, involved in the cellular response to oxidative stress. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine could upregulate ACOT12 expression by influencing adenosine receptor signaling and subsequent intracellular cAMP levels. | ||||||