AChRα1 Inhibitors
AChRα1 inhibitors constitute a diverse class of chemicals with distinctive mechanisms targeting the acetylcholine receptor alpha-1 subtype. These inhibitors directly or indirectly modulate AChRα1 function, disrupting normal cholinergic signaling. Compounds like Curare and α-Bungarotoxin act as direct inhibitors by competitively binding to the AChR, preventing acetylcholine from exerting its effects and inducing neuromuscular blockade. Dihydro-β-erythroidine competes reversibly with acetylcholine, decreasing AChR activation. In contrast, Hexamethonium, an indirect inhibitor, disrupts autonomic nervous system transmission by blocking nicotinic AChRs in ganglia, impacting AChRα1-containing receptors.
Non-depolarizing neuromuscular blockers, including Tubocurarine, Mivacurium, Pancuronium, Vecuronium, and Gallamine, competitively inhibit AChRα1, inducing muscle relaxation. These agents interfere with nerve impulse transmission at the neuromuscular junction. Additionally, muscarinic receptor antagonists such as Pirenzepine, Scopolamine, and Tropicamide indirectly modulate AChRα1 by selectively inhibiting muscarinic receptors, influencing cholinergic signaling in tissues where muscarinic receptors predominate. This results in decreased responsiveness to acetylcholine, affecting AChRα1-containing receptors. The multifaceted actions of AChRα1 inhibitors offer valuable insights into the intricate regulation of cholinergic signaling pathways and have implications for various physiological processes governed by AChRα1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Bungarotoxin | 11032-79-4 | sc-202897 | 1 mg | $351.00 | 5 | |
α-Bungarotoxin is a snake venom neurotoxin that acts as a potent antagonist for the AChRα1 subtype. It binds irreversibly to the AChR, inhibiting its function by preventing acetylcholine from binding. This toxin induces long-lasting blockade of neuromuscular transmission, leading to paralysis. | ||||||
Hexamethonium chloride | 60-25-3 | sc-263383 | 5 g | $32.00 | ||
Hexamethonium is a ganglionic blocking agent that inhibits nicotinic AChRs in autonomic ganglia. By blocking these receptors, Hexamethonium disrupts autonomic nervous system transmission, resulting in decreased activation of postganglionic neurons. The inhibition of nicotinic AChRs prevents the normal transmission of acetylcholine, leading to decreased autonomic responses. | ||||||
(+)-Tubocurarine chloride pentahydrate | 6989-98-6 | sc-216029 sc-216029A | 250 mg 1 g | $132.00 $398.00 | ||
Tubocurarine is a non-depolarizing neuromuscular blocking agent that inhibits AChR function by binding competitively and reversibly to the receptor. This prevents acetylcholine from activating the receptor, leading to neuromuscular blockade and muscle paralysis. | ||||||
Pirenzepine Dihydrochloride | 29868-97-1 | sc-204197 | 100 mg | $69.00 | 3 | |
Pirenzepine is a muscarinic receptor antagonist that indirectly modulates AChRα1 function by selectively inhibiting M1 muscarinic receptors. By blocking these receptors, Pirenzepine reduces the effects of acetylcholine in muscarinic-mediated pathways. | ||||||
Scopolamine | 51-34-3 | sc-473216 sc-473216A sc-473216B | 100 mg 500 mg 1 g | $172.00 $506.00 $786.00 | 2 | |
Scopolamine is a muscarinic receptor antagonist that indirectly modulates AChRα1 function by selectively inhibiting muscarinic receptors. By blocking these receptors, Scopolamine reduces the effects of acetylcholine in muscarinic-mediated pathways. | ||||||
Tropicamide | 1508-75-4 | sc-202371 | 100 mg | $32.00 | 3 | |
Tropicamide is a muscarinic receptor antagonist that indirectly modulates AChRα1 function by selectively inhibiting muscarinic receptors. By blocking these receptors, Tropicamide reduces the effects of acetylcholine in muscarinic-mediated pathways. | ||||||