AChRα1 Activators
AChRα1 activators constitute a diverse class of chemicals with unique mechanisms targeting the acetylcholine receptor alpha-1 subtype. These activators, including muscarinic and nicotinic receptor agonists and acetylcholinesterase inhibitors, directly or indirectly enhance AChRα1 functional activity. Compounds like Pilocarpine and Bethanechol directly activate AChRα1 by binding to and stimulating muscarinic receptors, mimicking the action of acetylcholine. Neostigmine, Rivastigmine, and other acetylcholinesterase inhibitors indirectly enhance AChRα1 activity by preventing the breakdown of acetylcholine, leading to sustained receptor activation.
On the other hand, nicotinic receptor agonists such as Epibatidine and Nicotine directly activate AChRα1 by binding to and stimulating nicotinic receptors. Dual-acting compounds like Carbachol, which activate both muscarinic and nicotinic receptors, provide a versatile approach to enhancing AChRα1 functional activity. These AChRα1 activators play a crucial role in modulating cholinergic signaling pathways, contributing to increased responsiveness in tissues expressing AChRα1. The multifaceted actions of AChRα1 activators offer valuable insights into the intricate regulation of cholinergic transmission and have implications for various physiological processes governed by AChRα1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pilocarpine | 92-13-7 | sc-479256 | 100 mg | $250.00 | 1 | |
Pilocarpine, a muscarinic acetylcholine receptor agonist, directly activates AChRα1 by binding to and stimulating muscarinic receptors. In particular, Pilocarpine enhances AChRα1 activity by mimicking the action of acetylcholine, leading to receptor activation and downstream signaling events. This agonist initiates signal transduction cascades that enhance the functional activity of AChRα1, promoting cholinergic responses in various tissues. | ||||||
(S)-Rivastigmine | 123441-03-2 | sc-472567 | 500 mg | $300.00 | ||
Rivastigmine, an acetylcholinesterase inhibitor, indirectly enhances AChRα1 activity by preventing the degradation of acetylcholine. Similar to Neostigmine, Rivastigmine prolongs the presence of acetylcholine at the neuromuscular junction, leading to sustained activation of AChRα1. The inhibition of acetylcholinesterase by Rivastigmine indirectly increases cholinergic transmission, resulting in enhanced functional activity of AChRα1 in neuromuscular signaling pathways. | ||||||
Oxotremorine M | 63939-65-1 | sc-203656 | 100 mg | $148.00 | 3 | |
Oxotremorine, a muscarinic acetylcholine receptor agonist, directly activates AChRα1 by binding to and stimulating muscarinic receptors. Its action mimics acetylcholine, leading to enhanced AChRα1 activity and downstream signaling events. The direct activation of AChRα1 by Oxotremorine contributes to increased cholinergic responses in tissues expressing muscarinic receptors, highlighting its role as a specific enhancer of AChRα1 functional activity. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $120.00 $275.00 $380.00 $670.00 $1400.00 $3000.00 | 12 | |
Carbachol, a muscarinic and nicotinic acetylcholine receptor agonist, directly activates AChRα1 by binding to and stimulating both muscarinic and nicotinic receptors. This dual action enhances AChRα1 activity, initiating signaling events that promote receptor activation. Carbachol's direct activation of AChRα1 contributes to increased cholinergic responses, making it a versatile enhancer of AChRα1 functional activity in tissues expressing muscarinic and nicotinic receptors. | ||||||
Donepezil | 120014-06-4 | sc-279006 | 10 mg | $73.00 | 3 | |
Donepezil, an acetylcholinesterase inhibitor, indirectly enhances AChRα1 activity by preventing the degradation of acetylcholine. By inhibiting acetylcholinesterase, Donepezil prolongs the presence of acetylcholine at the neuromuscular junction, leading to sustained activation of AChRα1. This indirect activation occurs through the accumulation of acetylcholine, resulting in increased cholinergic transmission and enhanced functional activity of AChRα1 in neuromuscular signaling. | ||||||
Tacrine Hydrochloride | 1684-40-8 | sc-200172 sc-200172A | 1 g 5 g | $41.00 $138.00 | 6 | |
Tacrine, an acetylcholinesterase inhibitor, indirectly enhances AChRα1 activity by preventing the breakdown of acetylcholine. Similar to Donepezil, Tacrine prolongs the presence of acetylcholine at the neuromuscular junction, leading to sustained activation of AChRα1. The inhibition of acetylcholinesterase by Tacrine indirectly increases cholinergic transmission, resulting in enhanced functional activity of AChRα1 in neuromuscular signaling pathways. | ||||||
Physostigmine | 57-47-6 | sc-202764 | 5 mg | $363.00 | 5 | |
Physostigmine, an acetylcholinesterase inhibitor, indirectly enhances AChRα1 activity by preventing the deg radation of acetylcholine. Its inhibition of acetylcholinesterase leads to prolonged presence of acetylcholine at the neuromuscular junction, resulting in sustained activation of AChRα1. | ||||||
Edrophonium chloride | 116-38-1 | sc-207610 sc-207610A sc-207610B | 250 mg 1 g 5 g | $64.00 $164.00 $1062.00 | 4 | |
Edrophonium, an acetylcholinesterase inhibitor, indirectly enhances AChRα1 activity by preventing the breakdown of acetylcholine. Similar to other acetylcholinesterase inhibitors, Edrophonium prolongs the presence of acetylcholine at the neuromuscular junction, leading to sustained activation of AChRα1. | ||||||