Molecular structure of Edrophonium chloride, CAS Number: 116-38-1
Edrophonium chloride (CAS 116-38-1)
See product citations (4)
CAS Number:
116-38-1
Purity:
≥95%
Molecular Weight:
201.69
Molecular Formula:
C10H16ClNO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Edrophonium chloride is an acetycholinesterase (AChE) inhibitor. Edrophonium Chloride, the chloride salt variant of edrophonium, is a cholinesterase inhibitor known for its fast-acting and short-duration effects with parasympathomimetic activity. Its mechanism involves the prevention of acetylcholine breakdown through specific binding to the catalytic site. Studies have demonstrated its ability to inhibit AChE activity in various sources, including human red blood cells, purified calf forebrain, and purified octopus brain, with Ki values of 0.2 µM, 0.2 µM, and 0.4 µM, respectively.
Edrophonium chloride (CAS 116-38-1) References
- The complication rate of edrophonium testing for suspected myasthenia gravis. | Ing, EB., et al. 2000. Can J Ophthalmol. 35: 141-4; discussion 145. PMID: 10812483
- The effect of cholinergic enhancement during filling cystometry: can edrophonium chloride be used as a provocative test for overactive bladder? | Yossepowitch, O., et al. 2001. J Urol. 165: 1441-5. PMID: 11342893
- Studies in myasthenia gravis: use of edrophonium chloride (Tensilon) in differentiating myasthenic from cholinergic weakness. | OSSERMAN, KE. and KAPLAN, LI. 1953. AMA Arch Neurol Psychiatry. 70: 385-92. PMID: 13079360
- Studies in myasthenia gravis: edrophonium chloride (tensilon) test as a new approach to management. | OSSERMAN, KE., et al. 1953. J Mt Sinai Hosp N Y. 20: 165-72. PMID: 13097113
- Advantages of pyridostigmine bromide (mestinon) and edrophonium chloride (tensilon) in the treatment of transitory myasthenia gravis in the neonatal period. | MOORE, H. 1955. N Engl J Med. 253: 1075-6. PMID: 13272842
- Contraction of the oculorotary muscles and intraocular pressure. A tonographic and electromyographic study of the effect of edrophonium chloride (tensilon) and succinylcholine (anectine) on the intraocular pressure. | KORNBLUETH, W., et al. 1960. Am J Ophthalmol. 49: 1381-7. PMID: 14411062
- Edrophonium chloride for testing colonic contractile activity in man. | Bassotti, G., et al. 1991. Acta Physiol Scand. 141: 289-93. PMID: 1858502
- [Ocular myasthenia: diagnosis and treatment]. | Stojkovic, T. and Béhin, A. 2010. Rev Neurol (Paris). 166: 987-97. PMID: 21075410
- To Evaluate the Effect of Edrophonium on Blood Glucose Levels in Euglycemic Albino Rats Through OGTT. | Amoghimath, S., et al. 2015. J Clin Diagn Res. 9: FF04-7. PMID: 25738004
- Esophageal chest pain. Value of high-dose provocative testing with edrophonium chloride in patients with normal esophageal manometries. | Lee, CA., et al. 1987. Dig Dis Sci. 32: 682-8. PMID: 3595381
- Myasthenia gravis: lung-function studies without and with edrophonium chloride. | Magyar, P., et al. 1979. Eur Neurol. 18: 59-65. PMID: 436864
- Myasthenia gravis: protective effect of ipratropiumbromide (Atrovent) on airways obstruction caused by edrophonium chloride (Tensilon). | Szathmáry, I., et al. 1981. Eur Neurol. 20: 56-61. PMID: 6451430
- The effect of edrophonium chloride-induced chest pain on esophageal blood flow and motility. | Gustafsson, U. and Tibbling, L. 1997. Scand J Gastroenterol. 32: 104-7. PMID: 9051868
Inhibitor of:
AChE, Choactase, CHT1, COLQ, and PRiMA.Activator of:
AChRα1, AChRδ, CPM, and Ly-6I.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Edrophonium chloride, 250 mg | sc-207610 | 250 mg | $64.00 | |||
Edrophonium chloride, 1 g | sc-207610A | 1 g | $164.00 | |||
Edrophonium chloride, 5 g | sc-207610B | 5 g | $1062.00 |