Tacrine Hydrochloride CAS: 1684-40-8
MF: C13H14N2•HCl
MW: 234.70
An anticholinesterase (AChE) inhibitor.
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Tacrine Hydrochloride (CAS 1684-40-8)

Tacrine Hydrochloride | CAS 1684-40-8 is rated 5.0 out of 5 by 1.
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See product citations (5)
Alternate Names: 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride; Cognex; Romotal
Application: Tacrine Hydrochloride is an anticholinesterase (AChE) inhibitor
CAS Number: 1684-40-8
Purity: ≥98%
Molecular Weight: 234.70
Molecular Formula: C13H14N2•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

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Tacrine Hydrochloride has been shown to reversibly inhibit acetylcholine esterase (AChE). This compound has been reported to display hepatotoxicity, more specifically causing pericentral necrosis and fat degeneration of hepatocytes. Additionally, tacrine hydrochloride has demonstrated the ability to cause a decrease in liver glycogens and an increase in Heme Oxygenase 1. Other experiments suggest that tacrine hydrochloride causes functional and morphological changes in the endoplasmic reticulum, ribosome, and mitochondria of the liver via DNA synthesis impairment. Tacrine hydrochloride is an inhibitor of butyrylcholinesterase (BChE).


References

1. Summers, W.K., et al. 1986. N. Engl. J. Med. 315: 1241-1245. PMID: 2430180
2. Robertson, D.G., et al. 1998. Arch. Toxicol. 72: 362-371. PMID: 9657284
3. Lupp, A., et al. 2010. Arzneimittelforschung. 60: 229-237. PMID: 20533758

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), ethanol, PBS (pH 7.2) (~16 mg/ml), and methanol. Insoluble in DMSO, and DMF.
Storage :
Store at -20° C
Melting Point :
284-286° C (lit.)
IC50 :
Cholinesterase: IC50 = 27.1 nM (Equus caballus); Butyrylcholinesterase: IC50 = 19 nM (Equus caballus); Acetylcholinesterase: IC50 = 42.3 nM (Electrophorus electricus)
pK Values :
pKb: 9.64
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AR9532500
PubChem CID :
2723754
Merck Index :
14: 9024
MDL Number :
MFCD00150067
EC Number :
216-867-5
SMILES :
C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl

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Certificate of Analysis

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Tacrine Hydrochloride (CAS 1684-40-8)  Product Citations

See how others have used Tacrine Hydrochloride (CAS 1684-40-8). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 29407385  Xu, J.|Oda, S.|Yokoi, T.| et al. 2018. Toxicol In Vitro. 48: 286-301.

PMID: # 32717485  Eur J Med Chem. 112623.

PMID: # 31668517  Cell Chem Biol. 1664-1680.e4.

PMID: # 31919413  Cell Death Dis. 11: 2.

PMID: # 32987628  

Citations 1 to 5 of 5 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. This chemical is soluble in water (25 mg/ml), PBS (16 mg/ml), methanol, and ethanol, and is insoluble in DMF and DMSO. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-25

Please, I know tacrine is withdrawn from US and European markets, but i want to know if it is still available in some countries as a medicine as in Brazil or other countries?

Asked by: yoka
Thank you for your question. The medication tacrine is discontinued as a therapeutic. However, it's use as a research reagent is unaffected. We do not sell tacrine HCl for medicinal, therapeutic or diagnostic use, we only supply tacrine HCl for use as a research reagent. It can only be used in a research laboratory, and not purchased for personal, human or animal use as it is only of research grade. If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: [email protected] or by live chat directly on our website, www.scbt.com
Answered by: Technical Support
Date published: 2016-11-07

what about the availability of tacrine in markets of some countries or it is withdrawn from all countries?

Asked by: yoka
Thank you for your question. The medication tacrine is discontinued as a therapeutic. However, it's use as a research reagent is unaffected. We do not sell tacrine HCl for medicinal, therapeutic or diagnostic use, we only supply tacrine HCl for use as a research reagent. It can only be used in a research laboratory, and not purchased for personal, human or animal use as it is only of research grade. If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: [email protected] or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2016-10-31
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Rated 5 out of 5 by from Lupp et al Lupp et al. (PubMed ID 20533758) found that Tacrine Hydrochloride caused pericentral necrosis and fatty degeneration of hepatocytes and oxidative stress induction of heme oxygenase (HO)-1 by enhancing CYP1A, 2B1 and 3A2 expression. -SCBT Publication Review
Date published: 2015-02-22
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