Physostigmine is an alkaloid originally derived from the Calabar bean (Physostigma venenosum). Physostigmine is noted to act as a potent and reversible inhibitor of cholinesterase. Physostigmine is also reported to form a slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE). Physostigmine has been used as a positive control in a study investigating acetylcholinesterase inhibitors for potential antihelminthic drug targets. Additionally, as a parasympathomimetic compound, Physostigmine is reported to cross the blood-brain barrier.
1. Tamaddonfard, E. and Hamzeh-Gooshchi, N. 2010. Pharmacol Rep. 62: 858-863. PMID: 21098868
2. Valli, M., et al. 2011. Curr Med Chem. [Epub ahead of print]. PMID: 21728957
3. Kalogiannis, M., et al. 2011. PLoS ONE. 6: e18697. PMID: 21533254
Soluble in alcohol (1:10), chloroform (1:1), ether (1:30), and DMSO. Insoluble in water.
Store at 4° C
102-104° C (lit.)
~393.5° C at 760 mmHg (Predicted)
~1.2 g/cm3 (Predicted)
n20D 1.57 (Predicted)
α20D -77±1, c = 1.7% in chloroform; α25D -120 in benzene
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Kalogiannis et alKalogiannis et al. (PubMed ID 21533254) found that the cholinesterase inhibitor physostigmine increased the number of spontaneous behavioral arrests without influencing circuits that determine arrest duration in double orexin receptor knockout mice. -SCBT Publication Review
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