aC1 Activators
AC1 Activators encompasses a group of molecules that specifically interact with and modulate the activity of adenylate cyclase 1, an enzyme variant belonging to the broader family of adenylate cyclases. Adenylate cyclase 1 (AC1) is one of the several isoforms of the enzyme found in mammalian cells, which plays a crucial role in catalyzing the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP). cAMP acts as a secondary messenger involved in a multitude of cellular processes, including the regulation of metabolic pathways and gene transcription. AC1 activators, therefore, influence the intracellular levels of cAMP by targeting the AC1 enzyme, thereby affecting the signaling pathways that rely on this pivotal second messenger.
AC1 activators are characterized by their ability to bind to the AC1 enzyme and enhance its catalytic efficiency, leading to an increase in the production of cAMP from ATP. This enhancement can occur through a variety of mechanisms, which can include allosteric modulation, where the activator binds to a site other than the active site of the enzyme, causing a conformational change that increases the enzyme's activity. These molecules can be structurally diverse, and their interactions with AC1 may be influenced by multiple factors such as the presence of ions, other regulatory proteins, or specific cellular conditions. The precise modulation of AC1 by these activators is of significant interest for understanding the intricate network of intracellular signaling, as the dysregulation of cAMP levels can have profound effects on cellular function. AC1 activators thus represent a focal point for studies into the modulation of enzymes that are central to cellular signaling cascades.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased production of cAMP. The rise in cAMP levels indirectly enhances the activity of aC1 by stimulating protein kinase A (PKA), which can phosphorylate aC1 or associated regulatory proteins, thereby increasing aC1 functional activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate binds to its G protein-coupled receptors, initiating a signaling cascade that activates phospholipase C and protein kinase C (PKC). PKC activation can lead to the phosphorylation of aC1 or its modulators, thereby enhancing aC1 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that can reduce competitive kinase activity, thus alleviating inhibitory phosphorylation on aC1 or its pathway components, resulting in enhanced aC1 functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium/calmodulin-dependent protein kinases, which may directly or indirectly activate aC1 by phosphorylation or through modulation of its interacting partners. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that stimulates adenylate cyclase, leading to increased cAMP levels and subsequent activation of PKA. PKA can then target and enhance aC1 activity or function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of PKC, which can phosphorylate aC1 or its associated proteins, leading to an increase in aC1 functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation. The increased levels of these cyclic nucleotides can enhance aC1 activity through the activation of PKA and PKG. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator that can modulate the activity of transcription factors and other proteins involved in the signaling pathways of aC1, potentially leading to enhanced activity of aC1 through indirect regulation of its signaling environment. | ||||||
U-46619 | 56985-40-1 | sc-201242 sc-201242A | 1 mg 10 mg | $240.00 $1275.00 | 40 | |
U46619 is a thromboxane A2 analog that activates G protein-coupled receptors, leading to activation of phospholipase C and subsequent PKC activation. This cascade can result in increased aC1 activity through phosphorylation events. | ||||||
ZM 241385 | 139180-30-6 | sc-361421 sc-361421A | 5 mg 25 mg | $90.00 $349.00 | 1 | |
ZM 241385 is an antagonist of the adenosine A2A receptor, which can lead to disinhibition of downstream effectors and subsequent activation of signaling pathways that increase aC1 activity. | ||||||