ABCA4 Activators
ABCA4 Activators are a class of chemicals that indirectly support the function of the ATP-binding cassette transporter A4 (ABCA4), a protein primarily expressed in the photoreceptor cells of the retina. This class includes a variety of compounds, primarily characterized by their antioxidative, anti-inflammatory, and membrane-stabilizing properties, which are crucial in maintaining the conducive environment for ABCA4 function. These activators do not directly interact with ABCA4; instead, they work by modulating the cellular environment and gene expression pathways that are essential for the optimal activity of ABCA4.
The chemicals in this class, such as All-trans Retinoic Acid, Docosahexaenoic Acid, and Lutein, function by enhancing the health of retinal cells and their membranes. For example, compounds like Resveratrol and Curcumin exert antioxidative and anti-inflammatory effects, which are vital in reducing oxidative and inflammatory stress in the retina. This reduction in stress supports the stability and function of membrane-bound proteins like ABCA4. Similarly, compounds like Sulforaphane and Quercetin activate antioxidant response elements and reduce inflammation, thereby contributing to the maintenance of a healthy retinal environment. Others, such as Alpha-lipoic Acid and N-Acetyl-Cysteine, enhance the cellular antioxidant capacity, further supporting the function of ABCA4 by maintaining the redox balance in retinal cells. Tauroursodeoxycholic Acid and Astaxanthin also play a role in mitigating cellular stress responses and protecting against oxidative damage, respectively, thereby indirectly supporting the optimal functioning of ABCA4. Collectively, these compounds ensure the maintenance of photoreceptor health and membrane integrity, which is vital for the activity of ABCA4 in the visual cycle.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA, a metabolite of Vitamin A, is involved in the regulation of gene expression by activating retinoic acid receptors (RARs). Activation of these receptors can influence the expression of genes involved in visual cycle and retinal health, which are directly associated with ABCA4 function. | ||||||
Docosahexaenoic acid-d5 | 1197205-71-2 | sc-218259 sc-218259A sc-218259B | 50 µg 100 µg 1 mg | $139.00 $223.00 $889.00 | 3 | |
DHA, an omega-3 fatty acid, is a major structural component of retinal photoreceptor outer segment membranes. It plays a crucial role in modulating membrane fluidity and function, which is essential for the proper functioning of membrane-bound proteins like ABCA4. | ||||||
Xanthophyll | 127-40-2 | sc-220391 sc-220391A | 25 mg 100 mg | $250.00 $900.00 | 2 | |
Xanthophyll is concentrated in the macula of the retina and is known for its antioxidative properties. It helps protect retinal cells from oxidative stress, which can indirectly support ABCA4 function by maintaining the health of photoreceptors and their membranes, where ABCA4 is localized. | ||||||
Zeaxanthin | 144-68-3 | sc-205544 sc-205544A | 500 µg 1 mg | $270.00 $463.00 | 5 | |
Zeaxanthin, another xanthophyll carotenoid found in the retina, functions similarly to lutein. It helps in protecting photoreceptor cells from oxidative damage and thereby supports the optimal environment for ABCA4 activity by maintaining retinal cell health and membrane integrity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound found in grapes and berries, exhibits antioxidative properties. It modulates oxidative stress response pathways, thus indirectly supporting ABCA4 activity by protecting photoreceptor cells and their membranes from oxidative damage, which is critical for ABCA4's stability and function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a bioactive compound in turmeric, has anti-inflammatory and antioxidative properties. It modulates inflammatory pathways in retinal cells, indirectly supporting ABCA4 activity by reducing inflammation and oxidative stress, which can impact the health of photoreceptors and their membranes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, is known for its ability to activate antioxidant response elements. This action can indirectly benefit ABCA4 function by reducing oxidative stress in retinal cells, thus maintaining a conducive environment for its activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid found in many fruits and vegetables, has antioxidative and anti-inflammatory properties. It helps in maintaining retinal health, indirectly supporting ABCA4 activity by reducing oxidative and inflammatory stress in the retina. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid, a naturally occurring compound, functions as an antioxidant. By reducing oxidative stress in retinal cells, it indirectly supports ABCA4 function, ensuring optimal photoreceptor health and membrane integrity where ABCA4 operates. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC, a precursor to glutathione, enhances the cellular antioxidant capacity. This action indirectly benefits ABCA4 by maintaining the redox balance in retinal cells, crucial for the stability and function of membrane proteins like ABCA4. | ||||||