ABCA17 Activators
Chemical activators of ATP-binding cassette, sub-family A member 17 engage various cellular pathways to modulate the activity of this protein. Phorbol 12-myristate 13-acetate, commonly known as PMA, and its twin compound Prostratin, activate protein kinase C (PKC). Upon activation, PKC can directly phosphorylate ATP-binding cassette, sub-family A member 17, leading to its enhanced activity. Similarly, Forskolin, by elevating intracellular cyclic AMP (cAMP) levels, leads to the activation of protein kinase A (PKA), which can then phosphorylate ATP-binding cassette, sub-family A member 17. Analogues of cAMP, such as 8-Bromo-cAMP and Dibutyryl-cAMP, bypass cellular receptors and directly activate PKA, resulting in a similar phosphorylation and activation of ATP-binding cassette, sub-family A member 17.
On the other hand, Ionomycin and A23187 increase intracellular calcium concentrations, which could engage calcium-dependent kinases to phosphorylate ATP-binding cassette, sub-family A member 17. Thapsigargin, by inhibiting the SERCA pump, also raises cytosolic calcium levels, potentially leading to the activation of ATP-binding cassette, sub-family A member 17 through calcium-mediated signaling pathways. Calyculin A and Okadaic acid, as phosphatase inhibitors, prevent the dephosphorylation of proteins, which could result in a prolonged phosphorylated state of ATP-binding cassette, sub-family A member 17, thereby sustaining its activity. Lastly, Fusicoccin induces the stabilization of 14-3-3 proteins with their target proteins, which may include kinases that phosphorylate ATP-binding cassette, sub-family A member 17, promoting its activation. Each of these chemicals, through their distinct mechanisms, converge on the phosphorylation state of ATP-binding cassette, sub-family A member 17, thus modulating its activity within the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC) which can phosphorylate and activate ATP-binding cassette, sub-family A member 17 in cells where this phosphorylation regulation mechanism is present. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium concentration, which can lead to the activation of calcium-dependent kinases that may phosphorylate and activate ATP-binding cassette, sub-family A member 17. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cAMP analog that activates PKA; PKA may phosphorylate and activate ATP-binding cassette, sub-family A member 17 by enhancing its ATPase activity if it is regulated by PKA-mediated phosphorylation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
A phosphatase inhibitor that can lead to an increased phosphorylation state of proteins, potentially including ATP-binding cassette, sub-family A member 17, leading to its activation if it is regulated by phosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits protein phosphatases 1 and 2A, leading to increased protein phosphorylation, which could activate ATP-binding cassette, sub-family A member 17 if it is subject to regulation by phosphorylation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent proteins that could phosphorylate and activate ATP-binding cassette, sub-family A member 17. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cAMP analog that diffuses into cells and activates PKA; the activated PKA may then phosphorylate and activate ATP-binding cassette, sub-family A member 17 if it is regulated by PKA-mediated phosphorylation. | ||||||
Fusicoccin | 20108-30-9 | sc-200754 sc-200754A sc-200754B | 1 mg 5 mg 10 mg | $416.00 $2081.00 $4162.00 | 7 | |
Stabilizes the interaction between 14-3-3 proteins and their partner proteins, which might include kinases that can phosphorylate and activate ATP-binding cassette, sub-family A member 17. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $141.00 $541.00 | 24 | |
Activates PKC, potentially leading to phosphorylation and subsequent activation of ATP-binding cassette, sub-family A member 17 if it is regulated by PKC-mediated phosphorylation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium concentration, which may activate calcium-sensitive proteins that could activate ATP-binding cassette, sub-family A member 17. | ||||||