A830053O21Rik Activators
A830053O21Rik Activators encompass a selection of chemical compounds that indirectly promote the functional activity of the protein via distinct signaling pathways. Forskolin and IBMX serve to elevate the levels of cAMP, a pivotal second messenger in cellular signaling. The increased cAMP activates protein kinase A (PKA), which in turn could phosphorylate substrates or regulators that enhance the activity of A830053O21Rik. Similarly, the polyphenol Epigallocatechin Gallate and Genistein inhibit kinase activities, which could reduce competitive phosphorylation and thus indirectly allow for A830053O21Rik's preferred activity within the cell. PMA, a PKC activator, and Staurosporine, a kinase inhibitor, selectively manipulate phosphorylation landscapes, which might favor A830053O21Rik activation by modifying the activity of proteins that interact with A830053O21Rik or its regulatory mechanisms.
Additionally, the PI3K inhibitor LY294002, along with MEK inhibitors PD 98059 and U0126, could shift cellular signaling in a manner that inadvertently leads to the enhancement of A830053O21Rikactivity by modulating alternative pathways or reducing competitive substrate phosphorylation. Compounds such as Sphingosine-1-phosphate engage lipid signaling pathways, which could intersect with pathways involving A830053O21Rik, thus enhancing its function. The modulation of calcium levels by A23187 and Thapsigargin, through different mechanisms, also has potential to enhance A830053O21Rik activity, as intracellular calcium signals are critical for numerous cellular processes. These A830053O21Rik Activators, through their targeted biochemical actions, facilitate the enhancement of A830053O21Rik's function by manipulating signaling pathways and cellular processes that converge on or influence the protein's activity, without necessitating direct binding or upregulation of the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases which increases intracellular cAMP by preventing its degradation. This cAMP accumulation can indirectly enhance A830053O21Rik activity by the same mechanism of PKA activation as Forskolin. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This polyphenol inhibits various protein kinases, potentially reducing competitive phosphorylation events, which may lead to an indirect enhancement of A830053O21Rik activity by allowing for its preferred phosphorylation or interaction with cellular targets. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which may phosphorylate proteins that modulate A830053O21Rik activity, thus indirectly enhancing its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which could lead to a compensatory response that enhances A830053O21Rik activity through alternative signaling pathways that are negatively regulated by PI3K. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which may lead to a shift in cellular signaling that indirectly enhances A830053O21Rik activity by reducing the phosphorylation of competing substrates. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is also an inhibitor of MEK1/2, potentially shifting signaling dynamics to favor pathways that could enhance A830053O21Rik function. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule can activate sphingosine kinase, leading to downstream signaling events that could enhance A830053O21Rik activity through lipid signaling pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor, which might selectively enhance A830053O21Rik activity by inhibiting kinases that negatively regulate A830053O21Rik-associated pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent signaling pathways potentially enhancing A830053O21Rik activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels which may indirectly enhance A830053O21Rik activity through calcium signaling pathways. | ||||||