A20 Activators
Chemicals that can activate A20 operate via various cellular pathways, often interconnected but not always directly affecting the A20 gene. Some chemicals, like Curcumin and Resveratrol, primarily affect the NF-κB pathway, a key regulator of immune response. Inhibiting this pathway leads to an upregulation of A20, essentially counterbalancing the pro-inflammatory effect. This is a sort of checks-and-balances system in cellular regulation. Other chemicals, such as Sulforaphane and N-Acetylcysteine, act through antioxidant responses. They trigger the Nrf2 signaling pathway, which results in the upregulation of various antioxidative genes, including A20.
Another class of chemicals, exemplified by Anisomycin and Emodin, affect A20 through kinases like JNK and ERK. These kinases are involved in cellular stress responses, and their activation leads to a cascade of events that can ultimately result in the expression of A20. Berberine and Quercetin function via metabolic pathways like AMPK and PI3K/Akt, connecting energy status to immune response through the activation of A20.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Can induce A20 expression by inhibiting NF-κB signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Upregulates A20 via SIRT1 activation and NF-κB inhibition. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Can enhance Nrf2 signaling, contributing to A20 upregulation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Activates the JNK pathway, leading to A20 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Activates PI3K/Akt pathway, promoting A20 expression. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Can upregulate A20 through AMPK pathway activation. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Can inhibit MAPKs, leading to upregulation of A20. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
Increases A20 expression via antioxidant responses. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Activates ERK pathway, contributing to A20 expression. | ||||||