A-FABP Activators

Common A-FABP Activators include, but are not limited to Rosiglitazone CAS 122320-73-4, Troglitazone CAS 97322-87-7, Pioglitazone CAS 111025-46-8, Ciglitazone CAS 74772-77-3 and GW 9662 CAS 22978-25-2.

A-FABP activators are compounds that stimulate the activity or expression of A-FABP (Adipocyte Fatty Acid Binding Protein). A-FABP, also known as FABP4, is one of the members of the fatty acid-binding protein family, a group of small cytoplasmic proteins responsible for binding and transporting long-chain fatty acids within cells. These proteins play a critical role in lipid metabolism, facilitating the transport of fatty acids to specific cellular compartments for storage, oxidation, or further metabolism.

A-FABP is primarily expressed in adipocytes and macrophages, highlighting its importance in lipid metabolism within these cell types. In adipocytes, A-FABP is involved in the uptake, storage, and release of fatty acids, ensuring the efficient handling of these lipids in response to nutritional and hormonal cues. In macrophages, A-FABP plays a role in the regulation of inflammatory responses, linking lipid metabolism with inflammation. A-FABP activators, by increasing the activity or expression of this protein, can amplify its functions, influencing lipid homeostasis in adipocytes and the inflammatory processes in macrophages. Given the central role of lipids in various physiological processes and the link between metabolic and inflammatory pathways, understanding the function and regulation of A-FABP is of significant importance. A-FABP activators, with their ability to modulate the activity of this protein, offer valuable tools for dissecting the multifaceted roles of A-FABP in lipid metabolism, inflammatory responses, and the intricate interplay between these processes in various cellular contexts.