9130404H23Rik Inhibitors
Chemical inhibitors of thymocyte selection associated family member 3 disrupt its functional activity by targeting various components of the T-cell receptor signaling pathways. Wortmannin and LY294002, specifically, obstruct the pathway by inhibiting phosphoinositide 3-kinases (PI3K). This inhibition hampers the activation of downstream effectors crucial for T-cell maturation. Concurrently, Rapamycin exerts its effects by selectively inhibiting mammalian target of rapamycin (mTOR), a key molecule in the activation and differentiation of T-cells, which is critical in the pathway where thymocyte selection associated family member 3 is involved. Similarly, the compound PP2 targets Src family tyrosine kinases, enzymes integral to initiating the cascade of T-cell receptor signaling, resulting in the functional inhibition of thymocyte selection associated family member 3.
Further along these lines, Dasatinib, another broad-spectrum inhibitor, impedes Src family kinases and consequently the associated signaling processes. U0126 and PD98059 both target MEK1/2 and MEK, respectively, within the MAPK/ERK pathway, preventing the activation of ERK-a necessary step for T-cell receptor-mediated signaling in which thymocyte selection associated family member 3 plays a role. SP600125 and SB203580 interfere with the signaling cascade by inhibiting JNK and p38 MAP kinase, respectively, both of which are crucial in T-cell receptor signaling pathways. BAY 11-7082 disrupts NF-κB activation, a pivotal step in the signaling required for T-cell maturation. Lastly, Go6983 and Ro-31-8220 are both inhibitors of protein kinase C (PKC), with their action leading to the disruption of signaling pathways critical for T-cell development, thereby inhibiting the functional activity of thymocyte selection associated family member 3 within these pathways.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are upstream regulators in the T-cell receptor signaling pathway, a pathway where thymocyte selection associated family member 3 is involved. Inhibition of PI3K leads to reduced activation of downstream effectors that are important for T-cell maturation and selection, thereby functionally inhibiting thymocyte selection associated family member 3 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, which is involved in T-cell receptor signaling. By inhibiting PI3K, LY294002 disrupts the signaling cascade necessary for proper function and development of T-cells, leading to a functional inhibition of thymocyte selection associated family member 3's role in T-cell signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin selectively inhibits mTOR (mammalian target of rapamycin), which is a key signaling molecule in T-cell activation and differentiation. Through inhibition of mTOR, rapamycin hampers the downstream signaling that contributes to T-cell maturation, where thymocyte selection associated family member 3 is implicated, thereby leading to its functional inhibition. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases, which are important for T-cell receptor signaling. Inhibition of these kinases by PP2 disrupts the signaling pathway, leading to functional inhibition of thymocyte selection associated family member 3, which is involved in the development and maturation of T-cells. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor that targets Src family kinases. Its inhibition of these kinases impedes the T-cell receptor signaling pathway, thereby functionally inhibiting thymocyte selection associated family member 3, which plays a role in T-cell development. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are part of the MAPK/ERK pathway, a pathway that contributes to T-cell receptor signaling. By inhibiting MEK1/2, U0126 prevents the activation of ERK, leading to a functional inhibition of thymocyte selection associated family member 3 by disrupting T-cell receptor-mediated signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which works upstream of ERK in the MAPK pathway. This pathway is involved in the signaling of T-cell receptors, and the inhibition of MEK by PD98059 leads to functional inhibition of thymocyte selection associated family member 3 by blocking T-cell signaling processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK (c-Jun N-terminal kinase), which plays a role in T-cell receptor signaling. By inhibiting JNK, SP600125 disrupts the signaling cascade important for T-cell development, leading to functional inhibition of thymocyte selection associated family member 3. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase, which is involved in T-cell receptor signaling pathways. Inhibition of p38 MAP kinase by SB203580 disrupts the signaling necessary for T-cell maturation, thereby functionally inhibiting thymocyte selection associated family member 3. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation, which is crucial for T-cell development and function. By inhibiting NF-κB, BAY 11-7082 disrupts the signaling that thymocyte selection associated family member 3 requires for participating in T-cell maturation, leading to its functional inhibition. | ||||||