5830418K08Rik Inhibitors
Chemicals classified as Cep295 Inhibitors are not directly targeting Cep295 but rather influence cellular processes and structures that are integral to Cep295's function within the cell. Cep295 is known to be involved in the proper functioning of the centrosome, a critical cellular structure for microtubule organization and cell cycle progression. The listed compounds affect the stability and dynamics of microtubules or the regulation of cell cycle progression, which are processes that Cep295 is indirectly associated with.
Microtubule-targeting agents such as Nocodazole, Paclitaxel, Vinblastine, and Colchicine affect microtubule polymerization and stability, which are crucial for centrosome function and can impact the role of Cep295 in centrosome cohesion. Cyclin-dependent kinase inhibitors like Roscovitine and Purvalanol A, as well as spindle poisons such as Griseofulvin, Monastrol, and S-trityl-L-cysteine, alter the dynamics of cell cycle progression and mitotic spindle formation, which can indirectly affect Cep295 function in centrosome duplication and separation. Plk1 and Aurora kinase inhibitors, BI 2536 and ZM447439, target enzymes that are essential for centrosome maturation and separation, processes that are associated with the function of Cep295. Dimethylenastron, another Eg5 kinesin inhibitor, can lead to defects in centrosome dynamics, further influencing Cep295 activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Destabilizes microtubules, which can disrupt the centrosome function, indirectly affecting Cep295's role in microtubule organization. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and can disrupt normal centrosome function, potentially affecting Cep295-dependent processes. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Disrupts microtubule assembly, which can lead to centrosome dysfunction, indirectly inhibiting Cep295 activity. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds to tubulin and prevents microtubule polymerization, potentially disrupting Cep295's role in centrosome cohesion. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Inhibits cyclin-dependent kinases (CDKs) and can affect centrosome duplication, indirectly interfering with Cep295 function. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Interferes with microtubule function, which could affect the centrosomal activities dependent on Cep295. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Inhibits CDKs and can disrupt cell cycle progression, potentially affecting Cep295's role in centrosome duplication. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Inhibits Eg5 kinesin and can lead to defects in centrosome separation, indirectly affecting Cep295. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
Inhibits mitotic spindle formation, potentially impacting the function of centrosomes and Cep295 by extension. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
Inhibits Polo-like kinase 1 (Plk1) which is crucial for centrosome maturation, potentially affecting Cep295 activity. | ||||||