5430405G05Rik Inhibitors
Tmem74b inhibitors, as described in the context of indirect modulation, are chemicals that can influence the cellular environment or signaling pathways to modulate the function of transmembrane protein 74B. The chemicals listed act through various mechanisms that can alter the cellular milieu or the physical properties of cell membranes where Tmem74b resides. For instance, compounds such as cholesterol, Filipin, and MβCD affect membrane fluidity and the integrity of lipid rafts, which are critical for the proper localization and function of many transmembrane proteins.
By altering the lipid composition and biophysical properties of the membrane, these compounds can influence the behavior of Tmem74b, potentially modulating its activity or expression. Other chemicals like Genistein and U18666A disrupt specific signaling cascades or intracellular transport mechanisms that are essential for the functional regulation of membrane proteins. Inhibitors such as Dynasore and Brefeldin A target the endocytic pathway and Golgi apparatus, respectively, thus affecting the trafficking and surface expression of Tmem74b.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
Alters cell membrane fluidity and can affect transmembrane protein function. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Binds to cholesterol, disrupting lipid rafts and potentially affecting Tmem74b localization or function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor that can disrupt signal transduction pathways involving transmembrane proteins. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
Inhibits cholesterol transport and can disrupt intracellular trafficking of cholesterol-regulated proteins. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Can modulate membrane properties and influence transmembrane protein function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Inhibits dynamin, affecting clathrin-mediated endocytosis and potentially the trafficking of Tmem74b. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
Modulates sodium transport and cellular pH, affecting transmembrane protein function. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $199.00 $599.00 | 24 | |
Inhibits sphingomyelinase, affecting lipid rafts and potentially transmembrane protein function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Ionophore that disrupts intracellular ion gradients, affecting protein trafficking and function. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $50.00 $126.00 $246.00 $3500.00 | 7 | |
Binds to sterols, disrupting membrane integrity and potentially affecting transmembrane protein function. | ||||||