5133401N09Rik Inhibitors
Chemical inhibitors of 5133401N09Rik can modulate the activity of this protein through various biochemical mechanisms. Staurosporine, for example, is a broad-spectrum protein kinase inhibitor that can attenuate the kinase activity essential for 5133401N09Rik's function. Similarly, Bisindolylmaleimide I specifically targets protein kinase C, which may be involved in the phosphorylation cascade associated with 5133401N09Rik, leading to a reduction in its activity. LY294002 and Wortmannin are both inhibitors of phosphoinositide 3-kinases; by inhibiting PI3K, they disrupt downstream signaling pathways that 5133401N09Rik could be a part of, thus hindering its function. PD98059 and U0126, selective for MEK1/2, can prevent the activation of extracellular signal-regulated kinases that may be critical for the functional activity of 5133401N09Rik. Rapamycin, an mTOR inhibitor, can suppress the mTOR signaling pathway, which might be crucial for the function of 5133401N09Rik.
In the same vein, SB203580, by inhibiting p38 MAP kinase, can alter the activity of 5133401N09Rik if it is involved in the p38 MAPK pathway. SP600125's inhibition of c-Jun N-terminal kinase has a similar effect in preventing the phosphorylation of substrates within 5133401N09Rik's pathway. PP2, which targets Src family tyrosine kinases, can impede the phosphorylation events that are necessary for 5133401N09Rik's activity within its signaling network. Y-27632, a ROCK inhibitor, can reduce the functional activity of 5133401N09Rik by disrupting downstream effects on the cytoskeleton if 5133401N09Rik is part of the Rho/ROCK pathway. Lastly, PD173074 inhibits the fibroblast growth factor receptor tyrosine kinase, which can affect signaling pathways regulating the activity of 5133401N09Rik, thus leading to its functional inhibition. These inhibitors collectively contribute to the modulation of 5133401N09Rik's role in its respective biochemical pathways by targeting different enzymes and kinases involved in its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. It inhibits the kinase activity that 5133401N09Rik may be involved with, leading to a decrease in the protein's functional activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC). By inhibiting PKC, it can reduce the phosphorylation of downstream targets that 5133401N09Rik may act upon, thereby inhibiting its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, it can prevent the activation of downstream signaling pathways that 5133401N09Rik is involved in, leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK). By inhibiting MEK, the subsequent activation of ERK is prevented, which can inhibit the function of 5133401N09Rik if it is part of the ERK pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. By inhibiting mTOR, it can suppress downstream signaling that 5133401N09Rik is involved in, leading to inhibition of the protein's function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2. By inhibiting these kinases, it can prevent the activation of downstream proteins that are regulated by the same pathway as 5133401N09Rik, resulting in its inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. By inhibiting p38 MAP kinase, it can disrupt the signaling pathway that may involve 5133401N09Rik, leading to the inhibition of the protein's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By inhibiting JNK, it can prevent the phosphorylation of substrates that are within the same pathway as 5133401N09Rik, thus inhibiting the protein's activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor. By directly inhibiting PI3K, it can disrupt the downstream signaling involving 5133401N09Rik, leading to inhibition of the protein's function. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. By inhibiting these kinases, PP2 can prevent the phosphorylation of molecules within the signaling pathway that includes 5133401N09Rik, thereby inhibiting its function. | ||||||