4932429P05Rik Activators
Chemical activators of Protein Phosphatase 4 Regulatory Subunit 3C2 (PP4R3C2) can influence its activity through various intracellular signaling pathways. Okadaic Acid and Calyculin A, both potent inhibitors of certain protein phosphatases, can indirectly increase the activity of PP4R3C2 by preventing the dephosphorylation of its substrates. The resulting accumulation of phosphorylated proteins can enhance the substrate availability for PP4R3C2, thereby activating it. Similarly, Phorbol 12-myristate 13-acetate (PMA) acts on this protein by activating Protein Kinase C (PKC), which phosphorylates a range of target proteins. The phosphorylation changes induced by PKC can affect PP4R3C2, either by directly modifying it or its associated proteins, leading to an activation of its phosphatase activity.
On the other hand, Forskolin, 8-Bromo-cAMP, and Dibutyryl-cAMP function by elevating cyclic AMP (cAMP) levels within the cell, which in turn activates Protein Kinase A (PKA). Activated PKA can phosphorylate components of the protein complex that includes PP4R3C2, which can result in its activation. Additionally, Ionomycin and Thapsigargin raise intracellular calcium levels, which can activate phosphatases like calcineurin. Such calcium-dependent pathways may indirectly influence the activity of PP4R3C2 through complex phosphorylation and dephosphorylation cascades. Spermine NONOate releases nitric oxide (NO), which activates soluble guanylyl cyclase, increasing cyclic GMP (cGMP) levels and potentially influencing PP4R3C2 activity through Protein Kinase G (PKG) activation. Furthermore, Hydrogen Peroxide acts as an oxidant, modifying the redox state of phosphatases and potentially leading to structural changes that activate PP4R3C2. Lastly, Zinc Sulfate can modulate enzyme activities by direct binding, and Sodium Orthovanadate, by inhibiting tyrosine phosphatases, can alter phosphorylation dynamics within the cell, thereby affecting the activity profile of PP4R3C2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels which can activate protein phosphatase 4 regulatory subunit 3C2 by enhancing its substrate availability. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Like okadaic acid, inhibits protein phosphatases and thereby can indirectly activate protein phosphatase 4 regulatory subunit 3C2 through increased phosphorylated substrate levels. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC) which can phosphorylate proteins and possibly lead to the activation of protein phosphatase 4 regulatory subunit 3C2 within its signaling complex. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium, which can activate calcineurin, and thereby could lead to a cascade of dephosphorylation events involving protein phosphatase 4 regulatory subunit 3C2. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Inhibits the SERCA pump leading to increased cytosolic calcium, which can activate downstream phosphatases including protein phosphatase 4 regulatory subunit 3C2 through indirect pathways. | ||||||
Spermine NONOate | 136587-13-8 | sc-202816 sc-202816A | 5 mg 25 mg | $53.00 $196.00 | 5 | |
Releases NO, which can activate soluble guanylyl cyclase, increasing cGMP levels, and potentially influencing protein phosphatase 4 regulatory subunit 3C2 activity through PKG activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cAMP analog that activates PKA; PKA can then phosphorylate protein complexes that may include protein phosphatase 4 regulatory subunit 3C2, leading to its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Another cAMP analog that activates PKA, which could result in the activation of protein phosphatase 4 regulatory subunit 3C2 by altering its phosphorylation state within the complex. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Acts as an oxidizing agent, which can lead to oxidative modification of phosphatases and their regulators, potentially activating protein phosphatase 4 regulatory subunit 3C2. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can modulate the activity of various enzymes, including phosphatases, and might selectively activate protein phosphatase 4 regulatory subunit 3C2 through direct binding. | ||||||