4931407G18Rik Inhibitors
The chemical class referred to as Cabs1 Inhibitors includes a variety of compounds that can indirectly modulate the function of the Cabs1 protein through their effects on cellular calcium dynamics. Since Cabs1 is a calcium-binding protein, any alteration in intracellular calcium levels or calcium signaling can impact its activity. Compounds such as Verapamil, Nifedipine, Amlodipine, and Bepridil are recognized as calcium channel blockers, which can diminish the influx of calcium ions from the extracellular space into the cytoplasm, thereby potentially affecting the calcium-dependent activities of Cabs1.
On the other hand, agents like Dantrolene, Thapsigargin, and Ryanodine target specific components of the sarcoplasmic/endoplasmic reticulum, such as the ryanodine receptors and SERCA pumps, which are responsible for the storage and release of calcium within cells. By modulating these intracellular calcium stores, these compounds can influence the concentration of calcium ions available for binding to Cabs1. Additionally, 2-APB and TMB-8 are known to affect intracellular calcium signaling by inhibiting IP3 receptors and internal calcium release, which can also impact Cabs1.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
A calcium channel blocker that can inhibit the influx of calcium, potentially affecting the calcium-dependent functions of Cabs1. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Another calcium channel blocker that can alter intracellular calcium levels, indirectly impacting Cabs1 which binds calcium. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Ryanodine receptor antagonist that can modify calcium release from the sarcoplasmic reticulum, potentially altering the calcium signaling environment of Cabs1. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Inhibitor of IP3 receptors which can reduce calcium release from intracellular stores, indirectly affecting Cabs1 functions that depend on calcium signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
SERCA pump inhibitor that leads to an increase in cytosolic calcium concentration by preventing the re-uptake of calcium into the sarcoplasmic/endoplasmic reticulum, which may indirectly influence the activity of Cabs1. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Modulator of the ryanodine receptor that can disrupt calcium release from the sarcoplasmic/endoplasmic reticulum, potentially affecting Cabs1 activity. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $43.00 $129.00 | 10 | |
An intracellular calcium antagonist that can inhibit calcium release from internal stores, which may indirectly alter Cabs1 activity. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
Calcium channel blocker used to reduce calcium entry into cells, which can indirectly affect the calcium-dependent regulatory roles of Cabs1. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
A blocker of receptor-mediated calcium entry channels which may influence the intracellular calcium levels and, consequently, Cabs1 activity. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
A cell-permeable calcium chelator that can buffer intracellular calcium and thus may indirectly impact the calcium-binding ability of Cabs1. | ||||||